Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GCG | P01275 | 10/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | APLNR | P35414 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | GCGR | P47871 | 3/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12470860 | 0.83 | CA1 (0.49) | GCGGCGRCA1CA2 | |
| SCHEMBL12470824 | 0.83 | POLB (0.40) | POLBALDH1A1HSD17B10MEN1MAPT | |
| SCHEMBL11901181 | 0.75 | SRD5A2 (0.51) | POLBALDH1A1SMN1; SMN2MEN1TSHR | |
| SCHEMBL12071918 | 0.73 | POLB (0.69) | POLBALDH1A1SMN1; SMN2HSD17B10HTT | |
| SCHEMBL1485848 | 0.71 | POLB (0.65) | POLBALDH1A1SMN1; SMN2HSD17B10HTT | |
| SCHEMBL3214608 | 0.70 | POLB (0.64) | POLBALDH1A1SMN1; SMN2HSD17B10HTT | |
| SCHEMBL10422269 | 0.69 | POLB (0.63) | POLBALDH1A1SMN1; SMN2HSD17B10HTT | |
| SCHEMBL2703268 | 0.68 | POLB (0.61) | POLBALDH1A1SMN1; SMN2HSD17B10HTT | |
| SCHEMBL3129089 | 0.68 | POLB (0.61) | POLBALDH1A1SMN1; SMN2HSD17B10HTT | |
| SCHEMBL18158251 | 0.68 | POLB (0.74) | POLBALDH1A1SMN1; SMN2HTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2673260-A1 | GLUCAGON RECEPTOR MODULATOR | Pfizer Inc (US) | 2013-12-18 | — | — | EP | disclosed |
| WO-2012107850-A1 | GLUCAGON RECEPTOR MODULATOR | PFIZER INC. (US) | 2012-08-16 | — | — | WO | disclosed |