Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.40 |
| ▸ | PPARD | Q03181 | 3/20 | 0.39 |
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
| ▸ | PPARA | Q07869 | 2/20 | 0.39 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.39 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.39 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | GHSR | Q92847 | 1/20 | 0.37 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1247415 | 0.91 | TSHR (0.43) | TSHRNR1H4PPARDPPARGPPARA | |
| SCHEMBL1246307 | 0.88 | NR1H4 (0.44) | TSHRNR1H4PPARD | |
| SCHEMBL1245253 | 0.85 | CACNA1F (0.42) | TSHRNR1H4PPARDCACNA1FCACNA1D | |
| SCHEMBL3714448 | 0.85 | LPAR1 (0.41) | NR1H4PPARDPPARGPPARAENPP2 | |
| SCHEMBL1246452 | 0.83 | TSHR (0.45) | TSHRCACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL1247195 | 0.83 | HDAC1 (0.43) | — | |
| SCHEMBL1247341 | 0.83 | TSHR (0.43) | TSHRCACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL1246467 | 0.82 | NR1H4 (0.43) | NR1H4PPARD | |
| SCHEMBL1246323 | 0.81 | PPARD (0.39) | TSHRNR1H4PPARDPPARGPPARA | |
| SCHEMBL1247291 | 0.81 | SCN9A (0.41) | TSHRNR1H4PPARDCACNA1FCACNA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2462128-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-06-13 | — | — | EP | claimed |
| WO-2011017350-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-02-10 | — | — | WO | claimed |