Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 9/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | FABP1 | P07148 | 1/20 | 0.39 |
| ▸ | FABP4 | P15090 | 1/20 | 0.39 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.38 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.38 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.38 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.38 |
| ▸ | PPARD | Q03181 | 3/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1245358 | 0.95 | NR1H4 (0.42) | NR1H4PTGS2FABP1FABP4LPAR1 | |
| SCHEMBL1246307 | 0.94 | NR1H4 (0.44) | NR1H4PTGS2GPBAR1PPARDSCN9A | |
| SCHEMBL1246476 | 0.94 | NR1H4 (0.42) | NR1H4FABP1FABP4LPAR1LPAR2 | |
| SCHEMBL1245176 | 0.91 | NR1H4 (0.40) | NR1H4FABP1FABP4LPAR1LPAR2 | |
| SCHEMBL1246477 | 0.90 | NR1H4 (0.42) | NR1H4FABP1FABP4GPBAR1PPARD | |
| SCHEMBL1246346 | 0.89 | SCN9A (0.38) | NR1H4GPBAR1PPARDSCN9A | |
| SCHEMBL1247108 | 0.88 | SCN9A (0.40) | NR1H4GPBAR1PPARDSCN9A | |
| SCHEMBL1246194 | 0.88 | SCN9A (0.41) | NR1H4PTGS2GPBAR1SCN9A | |
| SCHEMBL1246465 | 0.88 | NR1H4 (0.45) | NR1H4FABP1GPBAR1PPARDSCN9A | |
| SCHEMBL1246303 | 0.88 | PPARD (0.46) | GPBAR1PPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2462128-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-06-13 | — | — | EP | claimed |
| WO-2011017350-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-02-10 | — | — | WO | claimed |