Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.40 |
| ▸ | ERCC1 | P07992 | 2/20 | 0.40 |
| ▸ | FEN1 | P39748 | 2/20 | 0.40 |
| ▸ | ERCC4 | Q92889 | 2/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | XDH | P47989 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1150688 | 0.77 | NPSR1 (0.48) | NPSR1KDM4CRNASEH1ERCC1FEN1 | |
| SCHEMBL4913697 | 0.77 | EGLN1 (0.41) | RNASEH1ERCC1FEN1ERCC4EGLN1 | |
| SCHEMBL1150589 | 0.75 | NPSR1 (0.42) | NPSR1KDM4CRNASEH1KDM4EALDH1A1 | |
| SCHEMBL24800386 | 0.75 | NPSR1 (0.42) | NPSR1KDM4CRNASEH1ERCC1FEN1 | |
| SCHEMBL24801218 | 0.75 | NPSR1 (0.42) | NPSR1KDM4CRNASEH1EGLN1KDM4E | |
| SCHEMBL13998902 | 0.73 | NPSR1 (0.54) | NPSR1KDM4CEGLN1KDM4EALDH1A1 | |
| SCHEMBL4907155 | 0.73 | ALDH1A1 (0.50) | NPSR1ERCC1FEN1ERCC4KDM4E | |
| SCHEMBL4920425 | 0.73 | NPSR1 (0.44) | NPSR1KDM4CRNASEH1ERCC1FEN1 | |
| SCHEMBL13041238 | 0.72 | NPSR1 (0.42) | NPSR1KDM4CRNASEH1ERCC1FEN1 | |
| SCHEMBL11732441 | 0.71 | NPSR1 (0.56) | NPSR1KDM4CRNASEH1ERCC1FEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119371360-A | 5, 6-Dihydroxypyrimidine compound and preparation method and application thereof | 暨南大学 | 2025-01-28 | — | — | CN | disclosed |
| US-20150218120-A1 | HIV INTEGRASE INHIBITORS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-08-06 | — | — | US | disclosed |
| US-20140142137-A1 | HIV INTEGRASE INHIBITORS | NATIONAL INSTITUTES OF HEALTH (US) | 2014-05-22 | — | — | US | disclosed |
| WO-2012106534-A2 | HIV INTEGRASE INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-08-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140142137-A1 | HIV INTEGRASE INHIBITORS | IMPDH1, TYMP, IMPA1 | NPSR1 4674/4885KDM4C 2491/4885RNASEH1 772/4885 |
| US-20150218120-A1 | HIV INTEGRASE INHIBITORS | IMPDH1, TYMP, IMPA1 | NPSR1 4674/4885KDM4C 2491/4885RNASEH1 772/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.