Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.41 |
| ▸ | ERCC1 | P07992 | 2/20 | 0.37 |
| ▸ | FEN1 | P39748 | 2/20 | 0.37 |
| ▸ | ERCC4 | Q92889 | 2/20 | 0.37 |
| ▸ | RNASEH1 | O60930 | 2/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2743303 | 0.82 | EGLN1 (0.37) | EGLN1ERCC1FEN1ERCC4HCAR2 | |
| SCHEMBL7824207 | 0.78 | HCAR2 (0.42) | EGLN1HCAR2ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL12472147 | 0.77 | NPSR1 (0.52) | EGLN1ERCC1FEN1ERCC4RNASEH1 | |
| SCHEMBL5477906 | 0.75 | ALDH1A1 (0.40) | EGLN1HCAR2ALDH1A1HPGDTSHR | |
| SCHEMBL7515527 | 0.75 | HCAR2 (0.38) | EGLN1HCAR2ALDH1A1 | |
| SCHEMBL11100217 | 0.74 | — | — | |
| SCHEMBL9589868 | 0.73 | HCAR2 (0.32) | EGLN1ERCC1FEN1ERCC4HCAR2 | |
| SCHEMBL15082052 | 0.70 | EGLN1 (0.42) | EGLN1HCAR2ALDH1A1HPGDTSHR | |
| SCHEMBL18305810 | 0.69 | ALDH1A1 (0.39) | EGLN1ERCC1FEN1ERCC4RNASEH1 | |
| SCHEMBL13788790 | 0.68 | PDE10A (0.36) | EGLN1ERCC1FEN1ERCC4RNASEH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080153783-A1 | Pyrimidyl Phosphonate Antiviral Compounds and Methods of Use | GILEAD SCIENCES, INC. (US) | 2008-06-26 | — | — | US | disclosed |
| US-20080076738-A1 | Phosphonate Analogs Of Hiv Integrase Inhibitor Compounds | GILEAD SCIENCES, INC. | 2008-03-27 | — | — | US | disclosed |
| CN-1934093-A | Pyrimidyl phosphonate antiviral compounds and methods of use | GILEAD SCIENCES INC (US) | 2007-03-21 | — | — | CN | disclosed |
| EP-1742642-A2 | PHOSPHONATE ANALOGS OF HIV INTEGRASE INHIBITOR COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2007-01-17 | — | — | EP | disclosed |
| US-20060116356-A1 | Phosphonate analogs of HIV integrase inhibitor compounds | GILEAD SCIENCES, INC. | 2006-06-01 | — | — | US | disclosed |
| US-20050282839-A1 | Pyrimidyl phosphonate antiviral compounds and methods of use | GILEAD SCIENCES, INC. | 2005-12-22 | — | — | US | disclosed |
| WO-2005117904-A2 | PHOSPHONATE ANALOGS OF HIV INTEGRASE INHIBITOR COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2005-12-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080153783-A1 | Pyrimidyl Phosphonate Antiviral Compounds and Methods of Use | TYMP, MTAP, PNP | EGLN1 2675/4885ERCC1 1162/4885FEN1 86/4885 |
| US-20050282839-A1 | Pyrimidyl phosphonate antiviral compounds and methods of use | TYMP, MTAP, PNP | EGLN1 2675/4885ERCC1 1162/4885FEN1 86/4885 |
| US-20060116356-A1 | Phosphonate analogs of HIV integrase inhibitor compounds | TYMP, PNP, PIKFYVE | EGLN1 3167/4885ERCC1 879/4885FEN1 60/4885 |
| US-20080076738-A1 | Phosphonate Analogs Of Hiv Integrase Inhibitor Compounds | TYMP, PNP, PIKFYVE | EGLN1 3167/4885ERCC1 879/4885FEN1 60/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.