Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 9/20 | 0.52 |
| ▸ | SCN5A | Q14524 | 6/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1246240 | 0.91 | SCN9A (0.54) | SCN9ASCN5ANTRK1NPSR1MAPT | |
| SCHEMBL1247566 | 0.90 | SCN9A (0.59) | SCN9ASCN5ANTRK1NPSR1MAPT | |
| SCHEMBL1245322 | 0.87 | SCN9A (0.57) | SCN9ASCN5ANTRK1NPSR1MAPT | |
| SCHEMBL1245296 | 0.87 | SCN9A (0.55) | SCN9ASCN5ANTRK1NPSR1MAPT | |
| SCHEMBL3706641 | 0.87 | LPAR1 (0.49) | SCN9ASCN5AMAPTMEN1KMT2A | |
| SCHEMBL1245178 | 0.86 | SCN9A (0.55) | SCN9ASCN5ANTRK1NPSR1MAPT | |
| SCHEMBL1245113 | 0.85 | SCN9A (0.54) | SCN9ASCN5AMAPTTDP1 | |
| SCHEMBL1246424 | 0.85 | SCN9A (0.52) | SCN9ASCN5ANTRK1MAPTGAA | |
| SCHEMBL11896359 | 0.85 | LPAR1 (0.53) | SCN9ASCN5ANPSR1 | |
| SCHEMBL1247125 | 0.84 | SCN9A (0.58) | SCN9ASCN5ANTRK1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2462128-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-06-13 | — | — | EP | claimed |
| WO-2011017350-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-02-10 | — | — | WO | claimed |