Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 9/20 | 0.59 |
| ▸ | SCN5A | Q14524 | 6/20 | 0.59 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1245322 | 0.92 | SCN9A (0.57) | SCN9ASCN5ANTRK1PTGS2MAPT | |
| SCHEMBL1247099 | 0.90 | SCN9A (0.53) | SCN9ASCN5ANTRK1GABRA5 | |
| SCHEMBL1247223 | 0.90 | SCN9A (0.52) | SCN9ASCN5ANTRK1PTGS2MAPT | |
| SCHEMBL1245362 | 0.89 | SCN9A (0.57) | SCN9ASCN5ANTRK1PTGS2MAPT | |
| SCHEMBL1247206 | 0.88 | SCN9A (0.61) | SCN9ASCN5ANTRK1MAPTGAA | |
| SCHEMBL1246454 | 0.88 | NPSR1 (0.48) | SCN9ASCN5ANTRK1MAPTNPSR1 | |
| SCHEMBL1247808 | 0.88 | SCN9A (0.56) | SCN9ASCN5ANTRK1MAPTGAA | |
| SCHEMBL1247214 | 0.88 | SCN9A (0.56) | SCN9ASCN5ANTRK1PTGS2MAPT | |
| SCHEMBL1246424 | 0.88 | SCN9A (0.52) | SCN9ASCN5ANTRK1MAPTGAA | |
| SCHEMBL1247125 | 0.87 | SCN9A (0.58) | SCN9ASCN5ANTRK1PTGS2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2462128-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-06-13 | — | — | EP | claimed |
| WO-2011017350-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-02-10 | — | — | WO | claimed |