Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 7/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12475734 | 0.87 | SMN1; SMN2 (0.51) | SMN1; SMN2RAB9ANPC1KDM4EPOLB | |
| SCHEMBL12475343 | 0.86 | RAB9A (0.65) | SMN1; SMN2RAB9ANPC1KDM4EPOLB | |
| SCHEMBL12475719 | 0.86 | RAB9A (0.50) | SMN1; SMN2RAB9ANPC1KDM4EPOLB | |
| SCHEMBL12475500 | 0.82 | SMN1; SMN2 (0.50) | SMN1; SMN2RAB9ANPC1KDM4EPOLB | |
| SCHEMBL12475650 | 0.81 | RAB9A (0.48) | SMN1; SMN2RAB9ANPC1KDM4EPOLB | |
| SCHEMBL12475559 | 0.80 | MAPT (0.48) | SMN1; SMN2RAB9ANPC1KDM4EPOLB | |
| SCHEMBL12475436 | 0.79 | GAA (0.52) | SMN1; SMN2RAB9ANPC1KDM4EPOLB | |
| SCHEMBL12475339 | 0.79 | MAPT (0.49) | SMN1; SMN2RAB9ANPC1KDM4EPOLB | |
| SCHEMBL12475304 | 0.79 | NPC1 (0.52) | SMN1; SMN2RAB9ANPC1KDM4EPOLB | |
| SCHEMBL12475713 | 0.79 | TRPM8 (0.70) | SMN1; SMN2RAB9ANPC1KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012109573-A1 | SUBSTITUTED THIAZOLES FOR USE AS ANTIVIRAL AGENTS | PURDUE RESEARCH FOUNDATION (US) | 2012-08-16 | — | — | WO | disclosed |