Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 2/20 | 0.30 |
| ▸ | CA1 | P00915 | 2/20 | 0.30 |
| ▸ | CA2 | P00918 | 2/20 | 0.30 |
| ▸ | MMP2 | P08253 | 2/20 | 0.30 |
| ▸ | CA9 | Q16790 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12477242 | 0.97 | CA12 (0.33) | ACECA12CA1CA2MMP2 | |
| SCHEMBL12477720 | 0.95 | MMP2 (0.36) | ACECA12CA1CA2MMP2 | |
| SCHEMBL28646794 | 0.95 | MMP2 (0.36) | ACECA12CA1CA2MMP2 | |
| SCHEMBL27574167 | 0.84 | MMP2 (0.35) | ACECA12CA1CA2MMP2 | |
| SCHEMBL7027254 | 0.83 | MMP2 (0.37) | ACECA12CA1CA2MMP2 | |
| SCHEMBL28453622 | 0.81 | TSHR (0.36) | CA12CA1CA2MMP2CA9 | |
| SCHEMBL4268951 | 0.81 | MMP2 (0.36) | ACECA12CA1CA2MMP2 | |
| SCHEMBL4265150 | 0.81 | MMP2 (0.36) | ACECA12CA1CA2MMP2 | |
| SCHEMBL4266943 | 0.81 | MMP2 (0.36) | ACECA12CA1CA2MMP2 | |
| SCHEMBL12477861 | 0.78 | SLC6A3 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2658857-B1 | SUBSTITUTED PURINE NUCLEOSIDES, PHOSPHOROAMIDATE AND PHOSPHORODIAMIDATE DERIVATIVES FOR TREATMENT OF VIRAL INFECTIONS | INHIBITEX INC (US) | 2016-11-02 | — | — | EP | disclosed |
| EP-2658857-A2 | SUBSTITUTED PURINE NUCLEOSIDES, PHOSPHOROAMIDATE AND PHOSPHORODIAMIDATE DERIVATIVES FOR TREATMENT OF VIRAL INFECTIONS | Inhibitex, Inc. (US) | 2013-11-06 | — | — | EP | disclosed |
| WO-2012092484-A2 | SUBSTITUTED PURINE NUCLEOSIDES, PHOSPHOROAMIDATE AND PHOSPHORODIAMIDATE DERIVATIVES FOR TREATMENT OF VIRAL INFECTIONS | INHIBITEX, INC. (US) | 2012-07-05 | — | — | WO | disclosed |