Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFD | P00746 | 5/20 | 0.47 |
| ▸ | HTR2C | P28335 | 8/20 | 0.45 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 5/20 | 0.42 |
| ▸ | HTR2A | P28223 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.36 |
| ▸ | XDH | P47989 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12480145 | 0.84 | CFD (0.52) | CFDFTOXDH | |
| SCHEMBL19233827 | 0.79 | HTR2C (0.49) | CFDHTR2CGID4HTR2BHTR2A | |
| SCHEMBL19234227 | 0.77 | HTR2C (0.43) | HTR2CGID4HTR2BHTR2AKDM4E | |
| SCHEMBL19233453 | 0.76 | GID4 (0.47) | CFDHTR2CGID4HTR2BHTR2A | |
| SCHEMBL12480127 | 0.74 | CFD (0.44) | CFDFTOXDH | |
| SCHEMBL30052460 | 0.74 | GID4 (0.55) | CFDHTR2CGID4HTR2BHTR2A | |
| SCHEMBL19210755 | 0.74 | GID4 (0.55) | CFDHTR2CGID4HTR2BHTR2A | |
| SCHEMBL19233964 | 0.74 | GID4 (0.55) | CFDHTR2CGID4HTR2BHTR2A | |
| SCHEMBL18116548 | 0.72 | HTR2C (0.48) | HTR2CHTR2BHTR2AKDM4E | |
| SCHEMBL19234226 | 0.72 | GID4 (0.43) | HTR2CGID4HTR2BHTR2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2661433-A1 | INDOLE COMPOUNDS OR ANALOGUES THEREOF USEFUL FOR THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION (AMD) | Novartis AG (CH) | 2013-11-13 | — | — | EP | disclosed |
| WO-2012093101-A1 | INDOLE COMPOUNDS OR ANALOGUES THEREOF USEFUL FOR THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION (AMD) | NOVARTIS AG (CH) | 2012-07-12 | — | — | WO | disclosed |