Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 10/20 | 0.42 |
| ▸ | KLK7 | P49862 | 1/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12479707 | 1.00 | FKBP1A (0.42) | FKBP1AKLK7MITFMAPTHTT | |
| SCHEMBL12480970 | 1.00 | FKBP1A (0.42) | FKBP1AKLK7MITFMAPTHTT | |
| SCHEMBL18578230 | 0.91 | FKBP1A (0.41) | FKBP1AMITFMAPTHTT | |
| SCHEMBL21789823 | 0.88 | FKBP1A (0.41) | FKBP1AKLK7MITFMAPTHTT | |
| SCHEMBL12480646 | 0.88 | FKBP1A (0.41) | FKBP1AKLK7MITFMAPTHTT | |
| SCHEMBL13967436 | 0.86 | FKBP1A (0.43) | FKBP1AKLK7PARP1CTSLABCB1 | |
| SCHEMBL12480719 | 0.86 | FKBP1A (0.43) | FKBP1AKLK7PARP1CTSLABCB1 | |
| SCHEMBL18591179 | 0.86 | FKBP1A (0.43) | FKBP1AKLK7PARP1CTSLMEN1 | |
| SCHEMBL18591180 | 0.86 | FKBP1A (0.43) | FKBP1AKLK7PARP1CTSLMEN1 | |
| SCHEMBL16635290 | 0.83 | IMPDH2 (0.40) | FKBP1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2661433-A1 | INDOLE COMPOUNDS OR ANALOGUES THEREOF USEFUL FOR THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION (AMD) | Novartis AG (CH) | 2013-11-13 | — | — | EP | disclosed |
| WO-2012093101-A1 | INDOLE COMPOUNDS OR ANALOGUES THEREOF USEFUL FOR THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION (AMD) | NOVARTIS AG (CH) | 2012-07-12 | — | — | WO | disclosed |