Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | IL1RN | P18510 | 1/20 | 0.33 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.33 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1338419 | 0.77 | TRPV4 (0.33) | TSHRHTTTRPV4 | |
| SCHEMBL17712034 | 0.76 | — | — | |
| SCHEMBL10463782 | 0.76 | HTR2C (0.40) | TSHRIL1RNERAP2ERAP1HTR2C | |
| SCHEMBL12484075 | 0.74 | MEN1 (0.42) | TSHR | |
| SCHEMBL21872141 | 0.73 | HSD11B1 (0.52) | HTTTRPV4 | |
| SCHEMBL21411491 | 0.73 | EPAS1 (0.33) | HTTIL1RNERAP2ERAP1 | |
| SCHEMBL29469794 | 0.73 | HSD11B1 (0.52) | HTTTRPV4 | |
| SCHEMBL9362769 | 0.72 | MEN1 (0.37) | TSHRHTR2C | |
| SCHEMBL26230854 | 0.72 | — | — | |
| SCHEMBL30509287 | 0.71 | HTR2C (0.40) | IL1RNERAP2ERAP1HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2678327-B9 | HETEROARYL DERIVATIVES AS ALPHA7 NACHR MODULATORS | LUPIN LTD (IN) | 2016-12-28 | — | — | EP | disclosed |
| EP-2678327-B1 | HETEROARYL DERIVATIVES AS ALPHA7 NACHR MODULATORS | LUPIN LTD (IN) | 2016-08-17 | — | — | EP | disclosed |
| EP-2678327-B1 | HETEROARYL DERIVATIVES AS ALPHA7 NACHR MODULATORS | LUPIN LTD (IN) | 2016-08-17 | — | — | EP | disclosed |
| US-9393247-B2 | Heteroaryl derivatives as alpha7 nAChR modulators | LUPIN LIMITED (IN) | 2016-07-19 | — | — | US | disclosed |
| US-9393247-B2 | Heteroaryl derivatives as alpha7 nAChR modulators | LUPIN LIMITED (IN) | 2016-07-19 | — | — | US | disclosed |
| US-20150231143-A1 | Heteroaryl Derivatives as Alpha7 NACHR Modulators | LUPIN LIMITED (IN) | 2015-08-20 | — | — | US | disclosed |
| US-20150231143-A1 | Heteroaryl Derivatives as Alpha7 NACHR Modulators | LUPIN LIMITED (IN) | 2015-08-20 | — | — | US | disclosed |
| US-9072731-B2 | Heteroaryl derivatives as alpha7 nAChR modulators | LUPIN LIMITED (IN) | 2015-07-07 | — | — | US | disclosed |
| US-9072731-B2 | Heteroaryl derivatives as alpha7 nAChR modulators | LUPIN LIMITED (IN) | 2015-07-07 | — | — | US | disclosed |
| EP-2678327-A1 | HETEROARYL DERIVATIVES AS ALPHA7 NACHR MODULATORS | Lupin Limited (IN) | 2014-01-01 | — | — | EP | disclosed |
| US-20130331387-A1 | HETEROARYL DERIVATIVES AS ALPHA7 NACHR MODULATORS | LUPIN LIMITED (IN) | 2013-12-12 | — | — | US | disclosed |
| WO-2012114285-A9 | HETEROARYL DERIVATIVES AS ALPHA7 NACHR MODULATORS | LUPIN LIMITED (IN) | 2012-10-18 | — | — | WO | disclosed |
| WO-2012114285-A1 | HETEROARYL DERIVATIVES AS ALPHA7 NACHR MODULATORS | LUPIN LIMITED (IN) | 2012-08-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130331387-A1 | HETEROARYL DERIVATIVES AS ALPHA7 NACHR MODULATORS | CHRNA7, CHRM1, CHRM2 | TSHR 392/4885HTT 1444/4885IL1RN 681/4885 |
| US-20150231143-A1 | Heteroaryl Derivatives as Alpha7 NACHR Modulators | CHRNA7, CHRM1, CHRM2 | TSHR 387/4885HTT 1574/4885IL1RN 679/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.