Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.82 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.82 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.82 |
| ▸ | HPGD | P15428 | 1/20 | 0.82 |
| ▸ | TSHR | P16473 | 1/20 | 0.82 |
| ▸ | RAB9A | P51151 | 1/20 | 0.82 |
| ▸ | HTR6 | P50406 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 5/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.49 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.48 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.48 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 2/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL980636 | 0.91 | KDM4E (0.70) | KDM4EALDH1A1HSD17B10HPGDTSHR | |
| SCHEMBL395397 | 0.91 | KDM4E (1.00) | KDM4EALDH1A1HSD17B10HPGDTSHR | |
| SCHEMBL10095259 | 0.85 | LMNA (0.68) | KDM4EALDH1A1HSD17B10HPGDTSHR | |
| SCHEMBL5068833 | 0.85 | ALDH1A1 (0.62) | KDM4EALDH1A1HSD17B10HPGDTSHR | |
| SCHEMBL8356932 | 0.84 | LMNA (0.73) | KDM4EALDH1A1HSD17B10HPGDTSHR | |
| SCHEMBL3178983 | 0.83 | KDM4E (0.60) | KDM4EALDH1A1HSD17B10HPGDTSHR | |
| SCHEMBL14915842 | 0.83 | KDM4E (0.67) | KDM4EALDH1A1HSD17B10HPGDTSHR | |
| SCHEMBL10095270 | 0.82 | ALDH1A1 (0.61) | KDM4EALDH1A1HSD17B10HPGDTSHR | |
| SCHEMBL4406870 | 0.81 | ABCG2 (0.60) | KDM4EALDH1A1HSD17B10HPGDTSHR | |
| SCHEMBL31323947 | 0.81 | LMNA (0.64) | KDM4EALDH1A1HSD17B10HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012114252-A1 | NOVEL INDOLE AND PYRROLOPYRIDINE AMIDES | ACTELION PHARMACEUTICALS LTD (CH) | 2012-08-30 | — | — | WO | disclosed |