Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 2/20 | 0.53 |
| ▸ | DRD2 | P14416 | 2/20 | 0.53 |
| ▸ | HTR7 | P34969 | 2/20 | 0.53 |
| ▸ | EED | O75530 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12486539 | 0.85 | BCHE (0.45) | — | |
| SCHEMBL12486031 | 0.83 | SLC22A1 (0.43) | DRD2ADRB2ADRB1TBXA2R | |
| SCHEMBL12484520 | 0.82 | BCHE (0.54) | — | |
| SCHEMBL12485686 | 0.81 | GID4 (0.46) | DRD2OPRM1ADRB2 | |
| SCHEMBL4709300 | 0.81 | SLC22A1 (0.59) | ADRB2 | |
| SCHEMBL12485011 | 0.80 | SLC22A1 (0.40) | DRD2ADRB2 | |
| SCHEMBL12486091 | 0.79 | KDM4E (0.60) | OPRM1ADRB2ADRB1HTR1AADRA2A | |
| SCHEMBL12485294 | 0.79 | SLC22A1 (0.42) | DRD2ADRB2 | |
| SCHEMBL8559156 | 0.79 | PRCP (0.66) | CHRM4DRD2HTR7OPRM1ADRB2 | |
| SCHEMBL4026022 | 0.77 | BCHE (0.67) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012114252-A1 | NOVEL INDOLE AND PYRROLOPYRIDINE AMIDES | ACTELION PHARMACEUTICALS LTD (CH) | 2012-08-30 | — | — | WO | disclosed |