Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.50 |
| ▸ | FBP1 | P09467 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 6/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | CCR6 | P51684 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | KIF20A | O95235 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12487153 | 1.00 | CYP1A2 (0.65) | CYP1A2CYP3A4HIF1AALDH1A1MAPT | |
| SCHEMBL12486647 | 0.89 | CYP1A2 (0.66) | CYP1A2CYP3A4HIF1AALDH1A1MAPT | |
| SCHEMBL12486650 | 0.89 | CYP1A2 (0.66) | CYP1A2CYP3A4HIF1AALDH1A1MAPT | |
| SCHEMBL13485336 | 0.79 | KIF20A (0.58) | CYP1A2CYP3A4HIF1AALDH1A1MAPT | |
| SCHEMBL623482 | 0.79 | ALDH1A1 (0.53) | CYP1A2CYP3A4HIF1AALDH1A1MAPT | |
| SCHEMBL623481 | 0.79 | ALDH1A1 (0.53) | CYP1A2CYP3A4HIF1AALDH1A1MAPT | |
| SCHEMBL12486817 | 0.79 | CYP1A2 (1.00) | CYP1A2CYP3A4HIF1AALDH1A1MAPT | |
| SCHEMBL12486820 | 0.79 | CYP1A2 (1.00) | CYP1A2CYP3A4HIF1AALDH1A1MAPT | |
| SCHEMBL364138 | 0.77 | MAPT (0.58) | CYP1A2CYP3A4HIF1AALDH1A1MAPT | |
| SCHEMBL364137 | 0.77 | MAPT (0.58) | CYP1A2CYP3A4HIF1AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9295754-B2 | Noggin inhibitory compositions for ossification and methods related thereto | EMORY UNIVERSITY (US) | 2016-03-29 | — | — | US | claimed |
| EP-2678050-B1 | NOGGIN BLOCKING COMPOSITIONS FOR OSSIFICATION AND METHODS RELATED THERETO | UNIV EMORY (US) | 2020-10-14 | — | — | EP | disclosed |
| US-9295754-B2 | Noggin inhibitory compositions for ossification and methods related thereto | EMORY UNIVERSITY (US) | 2016-03-29 | — | — | US | disclosed |
| US-20130337082-A1 | NOGGIN INHIBITORY COMPOSITIONS FOR OSSIFICATION AND METHODS RELATED THERETO | EMORY UNIVERSITY (US) | 2013-12-19 | — | — | US | disclosed |
| WO-2012116135-A9 | NOGGIN BLOCKING COMPOSITIONS FOR OSSIFICATION AND METHODS RELATED THERETO | EMORY UNIVERSITY (US) | 2013-01-10 | — | — | WO | disclosed |
| WO-2012116135-A2 | NOGGIN BLOCKING COMPOSITIONS FOR OSSIFICATION AND METHODS RELATED THERETO | EMORY UNIVERSITY (US) | 2012-08-30 | — | — | WO | disclosed |