Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | OXTR | P30559 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26025586 | 0.85 | HPGD (0.57) | HPGDALDH1A1LMNAHTT | |
| SCHEMBL3598235 | 0.85 | HPGD (0.57) | HPGDALDH1A1LMNAHTT | |
| SCHEMBL23394177 | 0.85 | HPGD (0.57) | HPGDALDH1A1LMNAHTT | |
| SCHEMBL26324134 | 0.84 | TDP1 (0.60) | HPGDTDP1ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL10857542 | 0.83 | HPGD (0.44) | HPGDTDP1ALDH1A1GAAGLA | |
| SCHEMBL10857532 | 0.82 | HPGD (0.44) | HPGDTDP1ALDH1A1GAAGLA | |
| SCHEMBL18280147 | 0.81 | MGLL (0.58) | — | |
| SCHEMBL27719125 | 0.81 | TDP1 (0.47) | TDP1LMNA | |
| SCHEMBL9354623 | 0.80 | ALDH1A1 (0.66) | HPGDALDH1A1LMNA | |
| SCHEMBL7619766 | 0.79 | TDP1 (0.49) | TDP1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012122075-A1 | LACTAM DERIVATIVES AS DGAT-1 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-09-13 | — | — | WO | disclosed |