Sugi Predict

Sugi Predict / Compounds / SCHEMBL12489163

SCHEMBL12489163

SCHEMBL12489163

Nc1ccc(-c2cc(Br)cnc2N)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ USP7 Q93009 4/20 0.53
▸ KMT2A Q03164 2/20 0.50
▸ HTT P42858 1/20 0.50
▸ FYN P06241 6/20 0.45
▸ MAP4K4 O95819 6/20 0.45
▸ MINK1 Q8N4C8 2/20 0.44
▸ TNIK Q9UKE5 2/20 0.44
▸ CYP1A2 P05177 1/20 0.44
▸ KCNH2 Q12809 1/20 0.44
▸ CHEK2 O96017 2/20 0.40
▸ MKNK1 Q9BUB5 1/20 0.40
▸ ALDH1A1 P00352 2/20 0.39
▸ KDM4E B2RXH2 1/20 0.39
▸ MEN1 O00255 1/20 0.39
▸ NPC1 O15118 1/20 0.39
▸ TP53 P04637 1/20 0.39
▸ MAPT P10636 1/20 0.39
▸ HPGD P15428 1/20 0.39
▸ RAB9A P51151 1/20 0.39
▸ SMN1; SMN2 Q16637 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2228665 0.87 USP7 (0.71) USP7KMT2AHTTFYNMAP4K4
SCHEMBL29857960 0.85 MAP4K4 (0.54) USP7KMT2AHTTFYNMAP4K4
SCHEMBL13968119 0.85 MAP4K4 (0.54) USP7KMT2AHTTFYNMAP4K4
SCHEMBL15359055 0.85 USP7 (0.60) USP7KMT2AHTTFYNMAP4K4
SCHEMBL26916746 0.83 FYN (0.53) USP7KMT2AHTTFYNMAP4K4
SCHEMBL29582823 0.83 FYN (0.53) USP7KMT2AHTTFYNMAP4K4
SCHEMBL1665775 0.82 USP7 (0.53) USP7KMT2AFYNMAP4K4MINK1
SCHEMBL2224558 0.81 MAP4K4 (0.57) USP7KMT2AHTTMAP4K4MINK1
SCHEMBL22820714 0.81 MAP4K4 (0.57) USP7KMT2AHTTFYNMAP4K4
SCHEMBL17255919 0.81 KMT2A (0.65) USP7KMT2AHTTFYNMAP4K4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111467346-B Pyridone derivatives with tetrahydropyranylmethyl groups 第一三共株式会社 2023-05-16 — — CN disclosed
CN-110041316-B TAM family kinase/CSF 1R kinase inhibitors and uses thereof 药捷安康(南京)科技股份有限公司 2022-04-19 — — CN disclosed
US-20220002277-A1 PYRIDONE DERIVATIVE HAVING TETRAHYDROPYRANYLMETHYL GROUP DAIICHI SANKYO COMPANY, LIMITED (JP) 2022-01-06 — — US disclosed
US-11208403-B2 Pyridone derivatives having tetrahydropyranylmethyl groups DAIICHI SANKYO COMPANY, LIMITED (JP) 2021-12-28 — — US disclosed
US-20210177828-A1 TAM FAMILY KINASE /AND CSF1R KINASE INHIBITOR AND USE THEREOF TRANSTHERA SCIENCES (NANJING), INC. (CN) 2021-06-17 — — US disclosed
EP-3168219-B1 PYRIDONE DERIVATIVE HAVING TETRAHYDROPYRANYL METHYL GROUP DAIICHI SANKYO CO LTD (JP) 2021-03-31 — — EP disclosed
EP-3741752-A1 TAM FAMILY KINASE /AND CSF1R KINASE INHIBITOR AND USE THEREOF Nanjing Transthera Biosciences Co., Ltd. (CN) 2020-11-25 — — EP disclosed
EP-3741752-A1 TAM FAMILY KINASE /AND CSF1R KINASE INHIBITOR AND USE THEREOF Nanjing Transthera Biosciences Co., Ltd. (CN) 2020-11-25 — — EP disclosed
CN-111467346-A Pyridone derivatives with tetrahydropyranylmethyl groups 第一三共株式会社 2020-07-31 — — CN disclosed
CN-106604920-B Pyridone derivatives with tetrahydropyranylmethyl groups 第一三共株式会社 2020-06-09 — — CN disclosed
US-8933103-B2 Pyridone derivatives DAIICHI SANKYO COMPANY, LIMITED (JP) 2015-01-13 — — US disclosed
EP-2810937-A1 PYRIDONE DERIVATIVE DAIICHI SANKYO COMPANY, LIMITED (JP) 2014-12-10 — — EP disclosed
EP-2810937-A1 PYRIDONE DERIVATIVE DAIICHI SANKYO COMPANY, LIMITED (JP) 2014-12-10 — — EP disclosed
CN-104185627-A pyridone derivatives DAIICHI SANKYO CO LTD 2014-12-03 — — CN disclosed
US-20140187529-A1 AMINOPYRAZINE COMPOUNDS LOCUS PHARMACEUTICALS, INC. (US) 2014-07-03 — — US disclosed
WO-2013162061-A1 BICYCLIC PYRIMIDINE COMPOUND 第一三共株式会社 (JP) 2013-10-31 — — WO disclosed
US-20130281428-A1 Pyridone Derivatives DAIICHI SANKYO COMPANY, LIMITED (JP) 2013-10-24 — — US disclosed
US-20130281428-A1 Pyridone Derivatives DAIICHI SANKYO COMPANY, LIMITED (JP) 2013-10-24 — — US disclosed
US-20130281428-A1 Pyridone Derivatives DAIICHI SANKYO COMPANY, LIMITED (JP) 2013-10-24 — — US disclosed
WO-2012121939-A2 AMINOPYRAZINE COMPOUNDS LOCUS PHARMACEUTICALS, INC. (US) 2012-09-13 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130281428-A1 Pyridone Derivatives AXL, PDXK, TYRO3 USP7 3824/4885KMT2A 3829/4885HTT 1827/4885
US-20220002277-A1 PYRIDONE DERIVATIVE HAVING TETRAHYDROPYRANYLMETHYL GROUP AXL, TYRO3, LCK USP7 4410/4885KMT2A 2465/4885HTT 2616/4885
US-20210177828-A1 TAM FAMILY KINASE /AND CSF1R KINASE INHIBITOR AND USE THEREOF CSF1R, CSF3R, FLT3 USP7 3271/4885KMT2A 906/4885HTT 4407/4885
US-20140187529-A1 AMINOPYRAZINE COMPOUNDS ITK, IL4I1, IL5 USP7 2338/4885KMT2A 1029/4885HTT 4258/4885
US-11208403-B2 Pyridone derivatives having tetrahydropyranylmethyl groups AXL, TYRO3, PDXK USP7 4188/4885KMT2A 2843/4885HTT 2352/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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