Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 3/20 | 0.57 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.49 |
| ▸ | SCD | O00767 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
| ▸ | PRSS12 | P56730 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.44 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.44 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.42 |
| ▸ | HPGDS | O60760 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1251024 | 0.87 | DGAT1 (0.62) | DGAT1CHEK1SCDJAK2TYK2 | |
| SCHEMBL1250265 | 0.78 | DGAT1 (0.58) | DGAT1SCDJAK2TYK2PRSS12 | |
| SCHEMBL1249081 | 0.77 | DGAT1 (0.60) | DGAT1SCDJAK2TYK2HDAC6 | |
| SCHEMBL1252157 | 0.77 | DGAT1 (0.71) | DGAT1HDAC6HDAC3HDAC7HDAC9 | |
| SCHEMBL1250162 | 0.77 | DGAT1 (0.65) | DGAT1SCDPRSS12HDAC6HDAC3 | |
| SCHEMBL1248424 | 0.76 | DGAT1 (0.67) | DGAT1NPC1ITGB1ITGA4ITGB7 | |
| SCHEMBL1251606 | 0.76 | DGAT1 (0.56) | DGAT1JAK2TYK2LMNAHPGDS | |
| SCHEMBL11407426 | 0.76 | DGAT1 (0.56) | DGAT1JAK2TYK2LMNAHPGDS | |
| SCHEMBL1250986 | 0.76 | DGAT1 (0.67) | DGAT1HDAC6HDAC3HDAC7HDAC9 | |
| SCHEMBL1251640 | 0.75 | DGAT1 (0.79) | DGAT1CHEK1HDAC6NPC1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8222248-B2 | Organic compounds | NOVARTIS AG (CH) | 2012-07-17 | — | — | US | disclosed |
| US-20110046133-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2011-02-24 | — | — | US | disclosed |
| US-20110046133-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2011-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110046133-A1 | ORGANIC COMPOUNDS | DGAT1, DGAT2, SOAT1 | DGAT1 1/4885CHEK1 4091/4885SCD 459/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.