Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 4/20 | 0.62 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.45 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.45 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | PRSS12 | P56730 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1251640 | 0.86 | DGAT1 (0.79) | DGAT1HDAC6CHEK1CYP3A4NPC1 | |
| SCHEMBL15252889 | 0.84 | DGAT1 (0.50) | DGAT1HDAC6ITGB1ITGA4ITGB7 | |
| SCHEMBL1250238 | 0.84 | DGAT1 (0.72) | DGAT1HDAC6CHEK1CYP3A4HDAC3 | |
| SCHEMBL1249943 | 0.80 | DGAT1 (0.69) | DGAT1HDAC6CYP3A4NPC1RAB9A | |
| SCHEMBL1249203 | 0.79 | DGAT1 (0.77) | DGAT1HDAC6CHEK1CYP3A4ITGB1 | |
| SCHEMBL1250223 | 0.79 | DGAT1 (0.56) | DGAT1HDAC6ITGB1ITGA4ITGB7 | |
| SCHEMBL1249086 | 0.79 | DGAT1 (0.79) | DGAT1CHEK1NR2E3 | |
| SCHEMBL1250958 | 0.78 | DGAT1 (0.69) | DGAT1HDAC6CHEK1CYP3A4ITGB1 | |
| SCHEMBL1250144 | 0.78 | DGAT1 (0.69) | DGAT1HDAC6CYP3A4ITGB1ITGA4 | |
| SCHEMBL1248743 | 0.78 | DGAT1 (0.65) | DGAT1HDAC6CYP3A4NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8222248-B2 | Organic compounds | NOVARTIS AG (CH) | 2012-07-17 | — | — | US | disclosed |
| US-20110046133-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2011-02-24 | — | — | US | disclosed |
| US-20110046133-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2011-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110046133-A1 | ORGANIC COMPOUNDS | DGAT1, DGAT2, SOAT1 | DGAT1 1/4885HDAC6 1155/4885CHEK1 4091/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.