Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | PIK3CD | O00329 | 11/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 11/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 10/20 | 0.45 |
| ▸ | MTOR | P42345 | 2/20 | 0.45 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.42 |
| ▸ | PARP11 | Q9NR21 | 2/20 | 0.42 |
| ▸ | PIK3C3 | Q8NEB9 | 3/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12078765 | 0.96 | KCNH2 (0.59) | KCNH2MAPK1PIK3CDPIK3CGPIK3CB | |
| SCHEMBL12495999 | 0.93 | KCNH2 (0.57) | KCNH2MAPK1PIK3CDPIK3CGPIK3CB | |
| SCHEMBL12495977 | 0.88 | MAPK1 (0.53) | KCNH2MAPK1PIK3CDPIK3CGPIK3CB | |
| SCHEMBL18112912 | 0.88 | MAPK1 (0.52) | KCNH2MAPK1PIK3CDPIK3CGPIK3CB | |
| SCHEMBL18123071 | 0.87 | MAPK1 (0.51) | KCNH2MAPK1PIK3CDPIK3CGPIK3CB | |
| SCHEMBL18112932 | 0.85 | KCNH2 (0.55) | KCNH2MAPK1PIK3CDPIK3CGPIK3CB | |
| SCHEMBL25060795 | 0.84 | ALOX5AP (0.50) | KCNH2MAPK1PIK3CDPIK3CGPIK3CB | |
| SCHEMBL25060659 | 0.84 | ALOX5AP (0.50) | KCNH2MAPK1PIK3CDPIK3CGPIK3CB | |
| SCHEMBL12077346 | 0.83 | MAPK1 (0.51) | KCNH2MAPK1MAPKAPK2PARP10PARP11 | |
| SCHEMBL12495172 | 0.83 | MAPK1 (0.51) | KCNH2MAPK1PIK3CDPIK3CGPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2681206-B1 | MST1 KINASE INHIBITORS AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS INC (US) | 2017-06-14 | — | — | EP | disclosed |
| EP-2681206-A1 | MST1 KINASE INHIBITORS AND METHODS OF THEIR USE | Lexicon Pharmaceuticals, Inc. (US) | 2014-01-08 | — | — | EP | disclosed |
| WO-2012121992-A1 | MST1 KINASE INHIBITORS AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS, INC. (US) | 2012-09-13 | — | — | WO | disclosed |