Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 11/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | FEN1 | P39748 | 11/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | ATR | Q13535 | 1/20 | 0.40 |
| ▸ | PRF1 | P14222 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25060659 | 1.00 | ALOX5AP (0.50) | ALOX5APMAPK1FEN1PIK3CDPIK3CG | |
| SCHEMBL18123071 | 0.91 | MAPK1 (0.51) | ALOX5APMAPK1FEN1PIK3CDPIK3CG | |
| SCHEMBL25060668 | 0.87 | MAPK1 (0.44) | ALOX5APMAPK1FEN1PIK3CDPIK3CG | |
| SCHEMBL25060796 | 0.84 | MAPK1 (0.46) | ALOX5APMAPK1FEN1PRF1 | |
| SCHEMBL12495639 | 0.84 | KCNH2 (0.55) | MAPK1FEN1PIK3CDPIK3CGPIK3CB | |
| SCHEMBL22580810 | 0.82 | MAPK1 (0.50) | ALOX5APMAPK1FEN1PRF1 | |
| SCHEMBL12078765 | 0.82 | KCNH2 (0.59) | MAPK1PIK3CDPIK3CGPIK3CBMTOR | |
| SCHEMBL22580839 | 0.81 | FEN1 (0.48) | ALOX5APMAPK1FEN1PIK3CDPRF1 | |
| SCHEMBL21062744 | 0.81 | MAPK1 (0.49) | ALOX5APMAPK1FEN1PRF1 | |
| SCHEMBL22580838 | 0.81 | FEN1 (0.41) | ALOX5APMAPK1FEN1PIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3724180-B1 | COMPOUNDS FOR THE DEGRADATION OF STK4 AND TREATMENT OF HEMATOLOGIC MALIGNANCIES | DANA FARBER CANCER INST INC (US) | 2023-02-22 | — | — | EP | disclosed |