Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | PIK3CD | O00329 | 12/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 12/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 12/20 | 0.49 |
| ▸ | MTOR | P42345 | 4/20 | 0.49 |
| ▸ | FEN1 | P39748 | 5/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | ALOX5AP | P20292 | 4/20 | 0.47 |
| ▸ | PIK3C3 | Q8NEB9 | 4/20 | 0.45 |
| ▸ | PRF1 | P14222 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25060795 | 0.91 | ALOX5AP (0.50) | MAPK1PIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL25060659 | 0.91 | ALOX5AP (0.50) | MAPK1PIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL12078765 | 0.90 | KCNH2 (0.59) | MAPK1PIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL25060668 | 0.89 | MAPK1 (0.44) | MAPK1PIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL18112932 | 0.88 | KCNH2 (0.55) | MAPK1PIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL12495977 | 0.88 | MAPK1 (0.53) | MAPK1PIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL22580810 | 0.87 | MAPK1 (0.50) | MAPK1FEN1ALOX5APPRF1 | |
| SCHEMBL18112912 | 0.87 | MAPK1 (0.52) | MAPK1PIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL12495639 | 0.87 | KCNH2 (0.55) | MAPK1PIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL22580839 | 0.86 | FEN1 (0.48) | MAPK1PIK3CDFEN1ALOX5APPRF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016161145-A1 | STK4 INHIBITORS FOR TREATMENT OF HEMATOLOGIC MALIGNANCIES | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2016-10-06 | — | — | WO | disclosed |