Alpha-Tocopherol

Alpha-Tocopherol

SCHEMBL124961

Cc1c(C)c2c(c(C)c1O)CC[C@@](C)(CCC[C@H](C)CCC[C@H](C)CCCC(C)C)O2.Cc1c(O)cc2c(c1C)OC(C)(CCCC(C)CCCC(C)CCCC(C)C)CC2

nearest known ligand 0.81

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.81
MAPT P10636 2/20 0.81
MEN1 O00255 2/20 0.81
KMT2A Q03164 2/20 0.81
TTPA P49638 2/20 0.81
GSTP1 P09211 1/20 0.81
USP2 O75604 1/20 0.81
THRB P10828 1/20 0.81
CYP2C9 P11712 1/20 0.81
CYP2C19 P33261 1/20 0.81
AKT1 P31749 7/20 0.77
PDPK1 O15530 2/20 0.77
PHLPP1 O60346 2/20 0.77
ILK Q13418 2/20 0.77
NR1I2 O75469 2/20 0.70
ALOX5 P09917 1/20 0.65
PDE4A P27815 1/20 0.59
PDE3A Q14432 1/20 0.59
GSTO1 P78417 1/20 0.58
PSEN1 P49768 2/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Gamma-Tocopherol SCHEMBL14580952 0.92 AKT1 (0.91) LMNAMAPTMEN1KMT2ATTPA
Gamma-Tocopherol SCHEMBL14695405 0.92 AKT1 (0.91) LMNAMAPTMEN1KMT2ATTPA
Gamma-Tocopherol SCHEMBL29373100 0.92 AKT1 (0.91) LMNAMAPTMEN1KMT2ATTPA
Gamma-Tocopherol SCHEMBL16430717 0.92 AKT1 (0.91) LMNAMAPTMEN1KMT2ATTPA
SCHEMBL15441242 0.92 AKT1 (0.91) LMNAMAPTMEN1KMT2ATTPA
Gamma-Tocopherol SCHEMBL29620131 0.92 AKT1 (0.91) LMNAMAPTMEN1KMT2ATTPA
Gamma-Tocopherol SCHEMBL39640 0.92 AKT1 (0.91) LMNAMAPTMEN1KMT2ATTPA
Gamma-Tocopherol SCHEMBL8408124 0.92 AKT1 (0.91) LMNAMAPTMEN1KMT2ATTPA
Gamma-Tocopherol SCHEMBL17874900 0.92 AKT1 (0.91) LMNAMAPTMEN1KMT2ATTPA
Gamma-Tocopherol SCHEMBL120346 0.92 AKT1 (0.91) LMNAMAPTMEN1KMT2ATTPA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019046303-A1 A METHOD FOR PREDICTING A SUBJECT'S RESPONSE TO SLC MODULATOR THERAPY THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2019-03-07 WO disclosed
EP-2424502-B1 COMPOSITIONS CONTAINING A MIXTURE OF LUTEIN AND ZEAXANTHINE AND COATED WITH CHOCOLATE GRAAL SRL (IT) 2018-03-28 EP disclosed
EP-2424502-A1 COMPOSITIONS CONTAINING A MIXTURE OF LUTEIN AND ZEAXANTHINE AND COATED WITH CHOCOLATE Graal Srl (IT) 2012-03-07 EP disclosed
WO-2010125516-A1 COMPOSITIONS CONTAINING A MIXTURE OF LUTEIN AND ZEAXANTHINE AND COATED WITH CHOCOLATE GRAAL SRL (IT) 2010-11-04 WO disclosed