Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 13/20 | 0.91 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.91 |
| ▸ | PHLPP1 | O60346 | 3/20 | 0.91 |
| ▸ | ILK | Q13418 | 3/20 | 0.91 |
| ▸ | LMNA | P02545 | 3/20 | 0.72 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.65 |
| ▸ | TTPA | P49638 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | USP2 | O75604 | 1/20 | 0.65 |
| ▸ | THRB | P10828 | 1/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.65 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.62 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Gamma-Tocopherol SCHEMBL14695405 | 1.00 | AKT1 (0.91) | AKT1PDPK1PHLPP1ILKLMNA | |
| Gamma-Tocopherol SCHEMBL120346 | 1.00 | AKT1 (0.91) | AKT1PDPK1PHLPP1ILKLMNA | |
| Gamma-Tocopherol SCHEMBL17874900 | 1.00 | AKT1 (0.91) | AKT1PDPK1PHLPP1ILKLMNA | |
| Gamma-Tocopherol SCHEMBL16430717 | 1.00 | AKT1 (0.91) | AKT1PDPK1PHLPP1ILKLMNA | |
| Gamma-Tocopherol SCHEMBL29373100 | 1.00 | AKT1 (0.91) | AKT1PDPK1PHLPP1ILKLMNA | |
| Gamma-Tocopherol SCHEMBL39640 | 1.00 | AKT1 (0.91) | AKT1PDPK1PHLPP1ILKLMNA | |
| Gamma-Tocopherol SCHEMBL8408124 | 1.00 | AKT1 (0.91) | AKT1PDPK1PHLPP1ILKLMNA | |
| SCHEMBL15441242 | 1.00 | AKT1 (0.91) | AKT1PDPK1PHLPP1ILKLMNA | |
| Gamma-Tocopherol SCHEMBL29620131 | 1.00 | AKT1 (0.91) | AKT1PDPK1PHLPP1ILKLMNA | |
| Gamma-Tocopherol SCHEMBL28686334 | 0.99 | AKT1 (0.89) | AKT1PDPK1PHLPP1ILKLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070037879-A1 | Use of gamma-tocopherol and its oxidative metabolite LLU-alpha in the treatment of disease | WECHTER WILLIAM J | 2007-02-15 | — | — | US | disclosed |
| US-20070037878-A1 | Use of gamma-tocopherol and its oxidative metabolite LLU-alpha in the treatment of disease | WECHTER WILLIAM J | 2007-02-15 | — | — | US | disclosed |
| US-20070037879-A1 | Use of gamma-tocopherol and its oxidative metabolite LLU-alpha in the treatment of disease | WECHTER WILLIAM J | 2007-02-15 | — | — | US | disclosed |
| US-20070037878-A1 | Use of gamma-tocopherol and its oxidative metabolite LLU-alpha in the treatment of disease | WECHTER WILLIAM J | 2007-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070037879-A1 | Use of gamma-tocopherol and its oxidative metabolite LLU-alpha in the treatment of disease | TTPA, LTA, GSTM1 | AKT1 3368/4885PDPK1 4164/4885PHLPP1 3614/4885 |
| US-20070037878-A1 | Use of gamma-tocopherol and its oxidative metabolite LLU-alpha in the treatment of disease | TTPA, LTA, GSTM1 | AKT1 3368/4885PDPK1 4164/4885PHLPP1 3614/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.