Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPL | P06858 | 3/20 | 0.41 |
| ▸ | LIPG | Q9Y5X9 | 3/20 | 0.41 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.34 |
| ▸ | NQO2 | P16083 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.31 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.31 |
| ▸ | P4HB | P07237 | 1/20 | 0.31 |
| ▸ | ANPEP | P15144 | 1/20 | 0.30 |
| ▸ | LAP3 | P28838 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | MPI | P34949 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21459066 | 0.73 | NQO2 (0.46) | LPLLIPGTRPM4NQO2P4HB | |
| SCHEMBL29414003 | 0.73 | NQO2 (0.46) | LPLLIPGTRPM4NQO2P4HB | |
| SCHEMBL732170 | 0.73 | LPL (0.47) | LPLLIPGANPEPLAP3KDM4E | |
| SCHEMBL19794330 | 0.73 | LPL (0.42) | LPLLIPGIRAK4PRMT5WDR77 | |
| SCHEMBL27343841 | 0.73 | LPL (0.40) | LPLLIPGNQO2IRAK4MEN1 | |
| SCHEMBL15400071 | 0.72 | LPL (0.47) | LPLLIPGIRAK4CYP1A2CYP2A6 | |
| SCHEMBL24211868 | 0.72 | TRPM4 (0.42) | LPLLIPGTRPM4NQO2P4HB | |
| SCHEMBL734336 | 0.70 | LPL (0.45) | LPLLIPGTRPM4ANPEPLAP3 | |
| SCHEMBL360716 | 0.70 | LPL (0.42) | LPLLIPGANPEPLAP3KDM4E | |
| SCHEMBL25992586 | 0.70 | TRPM4 (0.40) | LPLLIPGTRPM4NQO2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2681206-A1 | MST1 KINASE INHIBITORS AND METHODS OF THEIR USE | Lexicon Pharmaceuticals, Inc. (US) | 2014-01-08 | — | — | EP | disclosed |
| WO-2012121992-A1 | MST1 KINASE INHIBITORS AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS, INC. (US) | 2012-09-13 | — | — | WO | disclosed |