Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A11 | P48066 | 6/20 | 0.57 |
| ▸ | SLC6A13 | Q9NSD5 | 6/20 | 0.57 |
| ▸ | SLC6A12 | P48065 | 5/20 | 0.57 |
| ▸ | SLC6A1 | P30531 | 4/20 | 0.57 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.57 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.57 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.57 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.57 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | GABRP | O00591 | 1/20 | 0.35 |
| ▸ | GABRD | O14764 | 1/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.35 |
| ▸ | GABRE | P78334 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1249678 | 1.00 | SLC6A11 (0.57) | SLC6A11SLC6A13SLC6A12SLC6A1GABRA5 | |
| SCHEMBL1249680 | 1.00 | SLC6A11 (0.57) | SLC6A11SLC6A13SLC6A12SLC6A1GABRA5 | |
| SCHEMBL1251294 | 1.00 | SLC6A11 (0.57) | SLC6A11SLC6A13SLC6A12SLC6A1GABRA5 | |
| SCHEMBL1251296 | 1.00 | SLC6A11 (0.57) | SLC6A11SLC6A13SLC6A12SLC6A1GABRA5 | |
| SCHEMBL28807484 | 0.84 | SLC6A11 (0.57) | SLC6A11SLC6A13SLC6A12SLC6A1GABRA5 | |
| SCHEMBL994209 | 0.82 | SLC6A1 (0.41) | SLC6A11SLC6A13SLC6A12SLC6A1GABRA5 | |
| SCHEMBL994208 | 0.82 | SLC6A1 (0.41) | SLC6A11SLC6A13SLC6A12SLC6A1GABRA5 | |
| SCHEMBL994207 | 0.82 | SLC6A1 (0.41) | SLC6A11SLC6A13SLC6A12SLC6A1GABRA5 | |
| SCHEMBL9000290 | 0.82 | SLC6A1 (0.42) | SLC6A11SLC6A13SLC6A12SLC6A1GABRA5 | |
| SCHEMBL994942 | 0.81 | SLC6A1 (0.44) | SLC6A11SLC6A13SLC6A12SLC6A1GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2279737-B1 | Heterocyclic compounds that are active as beta lactamase inhibitors | NOVEXEL (FR) | 2012-10-31 | — | — | EP | disclosed |
| EP-2279737-A1 | Heterocyclic compounds that are active as beta lactamase inhibitors | NOVEXEL (FR) | 2011-02-02 | — | — | EP | disclosed |
| EP-1480644-B1 | NOVEL HETEROCYCLIC COMPOUNDS WHICH ARE ACTIVE AS INHIBITORS OF BETA+LACTAMASES | NOVEXEL (FR) | 2010-10-13 | — | — | EP | disclosed |
| EP-1480644-A2 | NOVEL HETEROCYCLIC COMPOUNDS WHICH ARE ACTIVE AS INHIBITORS OF BETA+LACTAMASES | Aventis Pharma S.A. (FR) | 2004-12-01 | — | — | EP | disclosed |
| EP-1307457-B1 | AZABICYCLIC COMPOUNDS, PREPARATION THEREOF AND USE AS MEDICINES, IN PARTICULAR AS ANTIBACTERIAL AGENTS | AVENTIS PHARMA SA (FR) | 2004-04-07 | — | — | EP | disclosed |
| WO-2003063864-A2 | HETEROCYCLIC COMPOUNDS WHICH ARE ACTIVE AS INHIBITORS OF BETA LACTAMASES | AVENTIS PHARMA S.A. (FR) | 2003-08-07 | — | — | WO | disclosed |
| EP-1307457-A1 | AZABICYCLIC COMPOUNDS, PREPARATION THEREOF AND USE AS MEDICINES, IN PARTICULAR AS ANTIBACTERIAL AGENTS | Aventis Pharma S.A. (FR) | 2003-05-07 | — | — | EP | disclosed |
| WO-2002010172-A1 | AZABICYCLIC COMPOUNDS, PREPARATION THEREOF AND USE AS MEDICINES, IN PARTICULAR AS ANTIBACTERIAL AGENTS | AVENTIS PHARMA SA (FR) | 2002-02-07 | — | — | WO | disclosed |