SLC6A11

Sodium- and chloride-dependent GABA transporter 3 · P48066 · SLC6A11 on Sugi Atlas →

15,977 patent compounds predicted against SLC6A11, 6,449 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL764125 SCHEMBL764125 0.52 8/20
SCHEMBL1735305 SCHEMBL1735305 0.50 8/20
SCHEMBL1735308 SCHEMBL1735308 0.50 8/20
SCHEMBL1249676 SCHEMBL1249676 0.57 6/20
SCHEMBL1249678 SCHEMBL1249678 0.57 6/20
SCHEMBL1249680 SCHEMBL1249680 0.57 6/20
SCHEMBL1251294 SCHEMBL1251294 0.57 6/20
SCHEMBL1251296 SCHEMBL1251296 0.57 6/20
SCHEMBL431287 SCHEMBL431287 0.54 5/20
SCHEMBL1493230 SCHEMBL1493230 0.54 5/20
SCHEMBL200896 SCHEMBL200896 0.50 5/20
SCHEMBL200897 SCHEMBL200897 0.50 5/20
SCHEMBL229034 SCHEMBL229034 0.50 5/20
SCHEMBL524569 SCHEMBL524569 0.47 5/20
SCHEMBL1086283 SCHEMBL1086283 0.46 5/20
SCHEMBL336991 SCHEMBL336991 0.43 5/20
SCHEMBL1067170 SCHEMBL1067170 0.40 5/20
SCHEMBL44023 SCHEMBL44023 0.69 4/20
SCHEMBL992028 SCHEMBL992028 0.50 4/20
SCHEMBL332280 SCHEMBL332280 0.48 4/20

Clinical trials — most relevant to SLC6A11 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Computational Assessment of GABA Receptor Modulation in PTSD PHASE4RECRUITING
The Effects of Levetiracetam on Alcohol Dependent Subjects PHASE4COMPLETED
Pharmacogenetic Treatment With Anti-Glutaminergic Agents for Comorbid PTSD & AUD PHASE3COMPLETED
Efficacy and Safety Study of Lamotrigine to Treat Trigeminal Neuralgia PHASE2/PHASE3COMPLETED
Study of NRTX-1001 Neural Cell Therapy in Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy (EPIC (EPIlepsy Cell Therapy)) PHASE3RECRUITING
First-in-Human Evaluation of an Astrocytic Glutamate Transporter (EAAT2) PET Tracer in Dementia PHASE1/PHASE2RECRUITING
Modulation of GABA-A Receptors in Parkinson Disease-Flumazenil Arm PHASE1/PHASE2COMPLETED
Efficacy of Bumetanide to Improve Cognitive Functions in Down Syndrome PHASE2RECRUITING
Effects of Baclofen on Presynaptic Inhibition in Humans PHASE2WITHDRAWN
Vigabatrin for Treatment of Cocaine Dependence PHASE2COMPLETED
Efficacy and Safety of Ramelteon Combined With Gabapentin in Treating Patients With Insomnia PHASE2COMPLETED
Pilot Study of Bumetanide for Newborn Seizures PHASE1COMPLETED
N-acetylcysteine (NAC) for Improving Cognitive Dysfunction in Schizophrenia PHASE1COMPLETED
Phenylbutyrate for Monogenetic Developmental and Epileptic Encephalopathy EARLY_PHASE1ACTIVE_NOT_RECRUITING
MEG Study of Acute STX209 Effects in ASD EARLY_PHASE1COMPLETED
Pharmacokinetic Drug-Drug Interaction Study to Identify Biomarkers of Kidney Transporters EARLY_PHASE1COMPLETED
Pharmacokinetics Study of Gamma-aminobutyric Acid nanCOMPLETED
GABA Biomarkers in Dravet Syndrome nanRECRUITING
Potential Synergistic Effect of Combined Blood Flow Restriction Training and Betaine Supplementation on Skeletal Muscle nanCOMPLETED
Analgesic Effect of Oxytocin Receptor Modulation nanCOMPLETED
CRF vs WCRF or PRF-DRG in CLBP of FJ Origin and RFA Failure of MBDR: Central Sensitization and Aberrant Nerve Sprouting nanUNKNOWN
Pharmacogenetic and Neurofunctional Brain Areas Study in Obese Patients With Binge Eating Disorder nanUNKNOWN
Investigations of the Pathophysiology of Gilles de la Tourette Syndrome. Part 1: Simultaneous PET and 3T MRI nanCOMPLETED
Clinical-Genetic Variation in GABA/Alcohol Sensitivity nanCOMPLETED
Insulin Detemir in Obesity Management nanACTIVE_NOT_RECRUITING
Pilot Study Evaluating Neuro-Imaging Correlates of Epigenetic Finding in Prediction of Chronic Postsurgical Pain nanUNKNOWN
A Study of Cases with Abnormal Serum Ammonia in Neonate and Children Attending Assiut University Children Hospital nanNOT_YET_RECRUITING
PET Imaging of GABA Receptors in Succinic Semialdehyde Dehydrogenase Deficiency nanCOMPLETED
SLC13A5 Deficiency Natural History Study - United States Only nanENROLLING_BY_INVITATION
Stem Cell Study of Genetics and Drug Addiction nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a SLC6A11 binder may also engage these)

ProteinNameSimilarity
P31649 1.000 P31649 →
P31647 1.000 P31647 →
SLC6A4 Sodium-dependent serotonin transporter 1.000 landscape →
P31646 1.000 P31646 →
P31650 1.000 P31650 →
P31661 1.000 P31661 →
P28570 1.000 P28570 →
Q03614 1.000 Q03614 →
SLC6A6 Sodium- and chloride-dependent taurine transporter 1.000 landscape →
Q9MYX0 1.000 Q9MYX0 →
P51143 1.000 P51143 →
O18875 1.000 O18875 →
P48057 1.000 P48057 →
Q9MZ34 1.000 Q9MZ34 →
SLC6A13 Sodium- and chloride-dependent GABA transporter 2 1.000 landscape →
Q61327 1.000 Q61327 →
P31652 1.000 P31652 →
P23977 1.000 P23977 →
P51905 1.000 P51905 →
B4JMC1 1.000 B4JMC1 →
O35316 1.000 O35316 →
Q00589 1.000 Q00589 →
P31643 1.000 P31643 →
Q8VBW1 1.000 Q8VBW1 →
B3NV41 1.000 B3NV41 →
P48029 1.000 P48029 →
Q9JMA9 1.000 Q9JMA9 →
B3MRS1 1.000 B3MRS1 →
B4NDL8 1.000 B4NDL8 →
Q9XT49 1.000 Q9XT49 →