Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 6/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 3/20 | 0.40 |
| ▸ | CA1 | P00915 | 3/20 | 0.40 |
| ▸ | CA2 | P00918 | 3/20 | 0.40 |
| ▸ | CA9 | Q16790 | 3/20 | 0.40 |
| ▸ | ALDH3A1 | P30838 | 2/20 | 0.40 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.40 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.40 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.40 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12497074 | 0.82 | HTR6 (0.48) | HTR6PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL12496576 | 0.76 | HTR6 (0.43) | HTR6PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL12497978 | 0.72 | PSEN1 (0.42) | HTR6PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL15565794 | 0.71 | AGTR1 (0.48) | HTR6PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL12496883 | 0.70 | CNR1 (0.50) | HTR6PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL12496692 | 0.69 | HTR6 (0.40) | HTR6PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL12496513 | 0.69 | HTR6 (0.41) | HTR6PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL12093313 | 0.67 | HTR6 (0.70) | HTR6PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL12496638 | 0.66 | HTR6 (0.44) | HTR6PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7460536 | 0.66 | MAPT (0.52) | HTR6PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012117216-A1 | N- (ARYLALKYL) - 1H- INDOLE- 2 - SULFONIC ACID AMIDE COMPOUNDS AND THEIR THERAPEUTIC USE AS CANNABINOID ALLOSTERIC MODULATORS | THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN (GB) | 2012-09-07 | — | — | WO | disclosed |