Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | CCR5 | P51681 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | TACR1 | P25103 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27228860 | 0.93 | OPRM1 (0.46) | TSHRALOX15ATMOPRM1CCR5 | |
| SCHEMBL14272919 | 0.91 | KMT2A (0.48) | TSHRALOX15ATMOPRM1CCR5 | |
| SCHEMBL13070850 | 0.90 | OPRM1 (0.47) | TSHRALOX15ATMOPRM1CCR5 | |
| SCHEMBL191607 | 0.90 | AKR1C3 (0.47) | TSHRALOX15ATMKMT2AMEN1 | |
| SCHEMBL13754273 | 0.89 | TSHR (0.44) | TSHRALOX15ATMKMT2AMEN1 | |
| SCHEMBL31382332 | 0.88 | OPRM1 (0.51) | TSHRALOX15ATMOPRM1CCR5 | |
| SCHEMBL13070849 | 0.86 | CCR5 (0.47) | TSHRALOX15ATMOPRM1CCR5 | |
| SCHEMBL654813 | 0.86 | KMT2A (0.59) | TSHRALOX15ATMKMT2AMEN1 | |
| SCHEMBL13070452 | 0.85 | OPRM1 (0.48) | TSHRALOX15ATMOPRM1CCR5 | |
| SCHEMBL654359 | 0.85 | CCR5 (0.47) | TSHRALOX15ATMCCR5KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103635472-B | Serine/threonine kinase inhibitor | 阵列生物制药公司 | 2018-01-12 | — | — | CN | disclosed |
| CN-104876934-B | A kind of nitrogen heterocyclic ring phenylpiperidine compound and preparation method and application | 山东大学 | 2017-08-11 | — | — | CN | disclosed |
| US-9133187-B2 | Serine/threonine kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2015-09-15 | — | — | US | disclosed |
| CN-104876934-A | Nitrogen-containing heterocyclic phenyl piperidine compound as well as preparation method and application thereof | UNIV SHANDONG | 2015-09-02 | — | — | CN | disclosed |
| EP-2681215-B1 | SERINE/THREONINE KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2015-04-22 | — | — | EP | disclosed |
| CN-103635472-A | Serine/threonine kinase inhibitors | ARRAY BIOPHARMA INC | 2014-03-12 | — | — | CN | disclosed |
| EP-2681215-A1 | SERINE/THREONINE KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2014-01-08 | — | — | EP | disclosed |
| US-20130338140-A1 | SERINE/THREONINE KINASE INHIBITORS | GENETECH, INC. (US) | 2013-12-19 | — | — | US | disclosed |
| WO-2012118850-A1 | SERINE/THREONINE KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2012-09-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130338140-A1 | SERINE/THREONINE KINASE INHIBITORS | MAP3K1, MAP3K2, MAP3K20 | TSHR 1564/4885ALOX15 4748/4885ATM 280/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.