Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.43 |
| ▸ | FLT1 | P17948 | 5/20 | 0.43 |
| ▸ | FLT4 | P35916 | 5/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.43 |
| ▸ | EHMT2 | Q96KQ7 | 6/20 | 0.42 |
| ▸ | EHMT1 | Q9H9B1 | 6/20 | 0.42 |
| ▸ | MET | P08581 | 6/20 | 0.42 |
| ▸ | AURKA | O14965 | 4/20 | 0.42 |
| ▸ | TEK | Q02763 | 4/20 | 0.42 |
| ▸ | LCK | P06239 | 3/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | LYN | P07948 | 1/20 | 0.42 |
| ▸ | FGR | P09769 | 1/20 | 0.42 |
| ▸ | AXL | P30530 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1894960 | 0.89 | AXL (0.42) | KDRFLT1FLT4FGFR2EHMT2 | |
| SCHEMBL13627390 | 0.88 | KDR (0.49) | KDRFLT1FLT4FGFR2MET | |
| SCHEMBL12502130 | 0.88 | FGFR2 (0.46) | KDRFLT1FLT4FGFR2MET | |
| SCHEMBL12503719 | 0.86 | KDR (0.43) | KDRFLT1FLT4FGFR2EHMT2 | |
| SCHEMBL1893505 | 0.80 | KDR (0.63) | KDRFLT1FLT4FGFR2MET | |
| SCHEMBL1891567 | 0.78 | FGFR2 (0.43) | KDRFLT1FLT4FGFR2EHMT2 | |
| SCHEMBL1894317 | 0.78 | KDR (0.67) | KDRFLT1FLT4FGFR2MET | |
| SCHEMBL1898319 | 0.78 | FGFR2 (0.44) | KDRFGFR2METAURKATEK | |
| SCHEMBL1898322 | 0.78 | FGFR2 (0.44) | KDRFGFR2METAURKATEK | |
| SCHEMBL3501428 | 0.77 | FGFR2 (0.43) | KDRFLT1FLT4FGFR2EHMT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7973160-B2 | Nitrogen-containing aromatic derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2011-07-05 | — | — | US | disclosed |
| US-20100197911-A1 | Nitrogen-Containing Aromatic Derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-08-05 | — | — | US | disclosed |
| US-7612092-B2 | Urea derivatives containing aromatic or heteroaromatic rings; 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide; prophylactic or therapeutic agent for a disease for which angiogenesis inhibition is effective | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2009-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100197911-A1 | Nitrogen-Containing Aromatic Derivatives | GNG2, GCG, FRG1 | KDR 2687/4885FLT1 1368/4885FLT4 3144/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.