⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL9807679 | 0.91 | MAPT (0.51) | — | |
| SCHEMBL450333 | 0.84 | — | — | |
| SCHEMBL31955606 | 0.84 | MAPT (0.44) | — | |
| SCHEMBL8101389 | 0.78 | MAPT (0.55) | — | |
| SCHEMBL10912378 | 0.78 | MAPT (0.41) | — | |
| SCHEMBL99907 | 0.78 | KMT2A (0.49) | — | |
| SCHEMBL2600439 | 0.78 | MAPT (0.44) | — | |
| SCHEMBL2736522 | 0.76 | MAPT (0.40) | — | |
| SCHEMBL2566463 | 0.76 | MAPT (0.46) | — | |
| SCHEMBL11694300 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 123 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260053932-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS INC (US) | 2026-02-26 | — | — | US | disclosed |
| US-12428423-B2 | 1H-imidazo[4,5-h]quinazoline compound as protein kinase inhibitor | SHENGKE PHARMACEUTICALS (JIANGSU) LTD. (CN) | 2025-09-30 | — | — | US | disclosed |
| US-12419960-B2 | Compounds and methods for the targeted degradation of androgen receptor and associated methods of use | ARVINAS OPERATIONS, INC. (US) | 2025-09-23 | — | — | US | disclosed |
| US-20250127903-A1 | SUBSTITUTED PIPERIDINE DEGRONIMERS FOR TARGET PROTEIN DEGRADATION | C4 THERAPEUTICS, INC. (US) | 2025-04-24 | — | — | US | disclosed |
| US-12048747-B2 | Substituted piperidine Degronimers for Target Protein degradation | C4 THERAPEUTICS, INC. (US) | 2024-07-30 | — | — | US | disclosed |
| CN-116783179-A | Compounds and methods for targeted degradation of androgen receptor proteins | 阿尔维纳斯运营股份有限公司 | 2023-09-19 | — | — | CN | disclosed |
| EP-4232445-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR PROTEIN | Arvinas Operations, Inc. (US) | 2023-08-30 | — | — | EP | disclosed |
| US-20230084249-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. | 2023-03-16 | — | — | US | disclosed |
| US-20220315584-A1 | 1H-IMIDAZO[4,5-H]QUINAZOLINE COMPOUND AS PROTEIN KINASE INHIBITOR | SHENGKE PHARMACEUTICALS (JIANGSU) LTD. (CN) | 2022-10-06 | — | — | US | disclosed |
| US-20220315584-A1 | 1H-IMIDAZO[4,5-H]QUINAZOLINE COMPOUND AS PROTEIN KINASE INHIBITOR | SHENGKE PHARMACEUTICALS (JIANGSU) LTD. (CN) | 2022-10-06 | — | — | US | disclosed |
| EP-0003253-B1 | HEXAHYDROAZEPINE, PIPERIDINE AND PYRROLIDINE DERIVATIVES AND PROCESSES FOR MAKING AND USING THEM | JOHN WYETH & BROTHER LIMITED (GB) | 1982-12-22 | — | — | EP | disclosed |
| US-4306097-A | 3-[2-Hydroxy-4-(substituted)phenyl]-cycloalkanol analgesic agents | PFIZER INC. (US) | 1981-12-15 | — | — | US | disclosed |
| EP-0021552-A1 | Hexahydroazepine, piperidine and pyrrolidine derivatives and processes for preparing them | JOHN WYETH & BROTHER LIMITED (GB) | 1981-01-07 | — | — | EP | disclosed |
| US-4197241-A | Hexahydroazepine, piperidine and pyrrolidine derivatives | JOHN WYETH & BROTHER LIMITED (GB) | 1980-04-08 | — | — | US | disclosed |
| US-4197239-A | Hexahydroazepine, piperidine and pyrrolidine derivatives | JOHN WYETH & BROTHER LIMITED (GB) | 1980-04-08 | — | — | US | disclosed |
| EP-0003738-A1 | Process for producing cyclohexane-1,3-diones or 3-alkoxy-2-cyclohexenones | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1979-09-05 | — | — | EP | disclosed |
| EP-0003253-A1 | Hexahydroazepine, piperidine and pyrrolidine derivatives and processes for making and using them | JOHN WYETH & BROTHER LIMITED (GB) | 1979-08-08 | — | — | EP | disclosed |
| US-4058666-A | INSECTICIDE | ZOECON CORPORATION (US) | 1977-11-15 | — | — | US | disclosed |
| US-4006188-A | Cycloalkenones | ZOECON CORPORATION (US) | 1977-02-01 | — | — | US | disclosed |
| US-4000174-A | NOVEL COMPOUNDS | ZOECON CORPORATION (US) | 1976-12-28 | — | — | US | disclosed |