Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | MT-CO2 | P00403 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL125003 | 0.91 | — | — | |
| SCHEMBL2566463 | 0.78 | MAPT (0.46) | MAPTALDH1A1MT-CO2 | |
| SCHEMBL450333 | 0.77 | — | — | |
| SCHEMBL31955606 | 0.77 | MAPT (0.44) | MAPTALDH1A1MT-CO2 | |
| SCHEMBL3943458 | 0.76 | MAPT (0.49) | MAPTALDH1A1MT-CO2 | |
| SCHEMBL14637386 | 0.73 | MAPT (0.43) | MAPTMT-CO2 | |
| SCHEMBL11902792 | 0.73 | MAPT (0.43) | MAPTMT-CO2 | |
| SCHEMBL6942981 | 0.72 | MAPT (0.60) | MAPTALDH1A1 | |
| SCHEMBL10912378 | 0.71 | MAPT (0.41) | MAPTALDH1A1CA1CA9 | |
| SCHEMBL99907 | 0.71 | KMT2A (0.49) | MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0278907-B1 | CYCLOHEXANE DIONES | CIBA-GEIGY AG (CH) | 1991-05-29 | — | — | EP | disclosed |
| EP-0126713-B1 | CYCLOHEXANEDIONE-CARBOXYLIC-ACID DERIVATIVES HAVING A HERBICIDAL AND PLANT GROWTH REGULATING ACTIVITY | CIBA-GEIGY AG (CH) | 1989-01-18 | — | — | EP | disclosed |
| EP-0278907-A1 | Cyclohexane diones | CIBA-GEIGY AG (CH) | 1988-08-17 | — | — | EP | disclosed |
| EP-0126713-A2 | Cyclohexanedione-carboxylic-acid derivatives having a herbicidal and plant growth regulating activity | CIBA-GEIGY AG (CH) | 1984-11-28 | — | — | EP | disclosed |