Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.50 |
| ▸ | MET | P08581 | 7/20 | 0.50 |
| ▸ | AURKA | O14965 | 3/20 | 0.50 |
| ▸ | LCK | P06239 | 3/20 | 0.50 |
| ▸ | TEK | Q02763 | 3/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 6/20 | 0.49 |
| ▸ | KIT | P10721 | 2/20 | 0.44 |
| ▸ | RET | P07949 | 2/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
| ▸ | NMT1 | P30419 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12503749 | 0.95 | KDR (0.51) | KDRMETAURKALCKTEK | |
| SCHEMBL12673683 | 0.94 | KDR (0.49) | KDRMETAURKALCKTEK | |
| SCHEMBL1896191 | 0.91 | KDR (0.51) | KDRMETAURKALCKTEK | |
| SCHEMBL12673814 | 0.89 | KDR (0.50) | KDRMETAURKALCKTEK | |
| SCHEMBL1895112 | 0.86 | KDR (0.52) | KDRMETAURKALCKTEK | |
| SCHEMBL14693167 | 0.85 | KDR (0.49) | KDRMETAURKALCKTEK | |
| SCHEMBL1893342 | 0.85 | KDR (0.51) | KDRMETAURKALCKTEK | |
| SCHEMBL12503492 | 0.85 | PDGFRA (0.50) | KDRMETLCKTEKAURKB | |
| SCHEMBL1894643 | 0.84 | KDR (0.53) | KDRMETAURKALCKTEK | |
| SCHEMBL13627611 | 0.84 | KDR (0.61) | KDRMETAURKALCKTEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7973160-B2 | Nitrogen-containing aromatic derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2011-07-05 | — | — | US | disclosed |
| US-20100197911-A1 | Nitrogen-Containing Aromatic Derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100197911-A1 | Nitrogen-Containing Aromatic Derivatives | GNG2, GCG, FRG1 | KDR 2687/4885MET 1810/4885AURKA 1006/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.