Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 5/20 | 0.62 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.55 |
| ▸ | GRM5 | P41594 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | COMT | P21964 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | HPSE | Q9Y251 | 2/20 | 0.49 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1250541 | 0.93 | DGAT1 (0.57) | DGAT1HDAC6GRM5KMT2ANPC1 | |
| SCHEMBL1248687 | 0.90 | HDAC6 (0.61) | DGAT1HDAC6GRM5KMT2ANPC1 | |
| SCHEMBL1251578 | 0.90 | DGAT1 (0.55) | DGAT1HDAC6GRM5KMT2AHDAC8 | |
| SCHEMBL1250909 | 0.87 | DGAT1 (0.77) | DGAT1HDAC6KMT2ANPC1RAB9A | |
| SCHEMBL1249424 | 0.86 | DGAT1 (0.82) | DGAT1HDAC6KMT2ANPC1RAB9A | |
| SCHEMBL1249335 | 0.86 | HDAC6 (0.53) | DGAT1HDAC6GRM5KMT2AHDAC8 | |
| SCHEMBL1250454 | 0.85 | DGAT1 (0.66) | DGAT1HDAC6KMT2ANPC1RAB9A | |
| SCHEMBL15252673 | 0.84 | KDR (0.53) | DGAT1KMT2ACOMTTP53AMY1A | |
| SCHEMBL1250057 | 0.84 | ATM (0.66) | DGAT1KMT2ANPC1RAB9ACOMT | |
| SCHEMBL1248809 | 0.84 | DGAT1 (0.71) | DGAT1HDAC6KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8222248-B2 | Organic compounds | NOVARTIS AG (CH) | 2012-07-17 | — | — | US | disclosed |
| US-20110046133-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2011-02-24 | — | — | US | disclosed |
| US-20110046133-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2011-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110046133-A1 | ORGANIC COMPOUNDS | DGAT1, DGAT2, SOAT1 | DGAT1 1/4885HDAC6 1155/4885GRM5 2359/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.