Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 5/20 | 0.38 |
| ▸ | RPTOR | Q8N122 | 5/20 | 0.38 |
| ▸ | MLST8 | Q9BVC4 | 5/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 4/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 4/20 | 0.33 |
| ▸ | FEN1 | P39748 | 4/20 | 0.33 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | TTK | P33981 | 1/20 | 0.31 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.30 |
| ▸ | WNT3A | P56704 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12503601 | 0.94 | MTOR (0.37) | MTORRPTORMLST8DGAT1 | |
| SCHEMBL2732777 | 0.92 | MTOR (0.45) | MTORRPTORMLST8DGAT1CHEK1 | |
| SCHEMBL15007356 | 0.91 | MTOR (0.35) | MTORRPTORMLST8DGAT1ALOX5AP | |
| SCHEMBL15026274 | 0.89 | ALOX5AP (0.35) | MTORRPTORMLST8DGAT1ALOX5AP | |
| SCHEMBL2147143 | 0.88 | MTOR (0.35) | MTORRPTORMLST8DGAT1 | |
| SCHEMBL10238471 | 0.88 | ALOX5AP (0.36) | DGAT1ALOX5APFEN1CHEK1CCNA2 | |
| SCHEMBL12503597 | 0.87 | MTOR (0.39) | MTORRPTORMLST8DGAT1CHEK1 | |
| SCHEMBL2706919 | 0.87 | MTOR (0.35) | MTORRPTORMLST8DGAT1 | |
| SCHEMBL2147472 | 0.85 | MTOR (0.34) | MTORRPTORMLST8 | |
| SCHEMBL12460795 | 0.85 | MTOR (0.34) | MTORRPTORMLST8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2608668-A1 | FUSED TRICYCLIC INHIBITORS OF MAMMALIAN TARGET OF RAPAMYCIN | Merck Sharp & Dohme Corp. (US) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012027234-A1 | FUSED TRICYCLIC INHIBITORS OF MAMMALIAN TARGET OF RAPAMYCIN | SCHERING CORPORATION (US) | 2012-03-01 | — | — | WO | disclosed |