Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 4/20 | 0.39 |
| ▸ | RPTOR | Q8N122 | 4/20 | 0.39 |
| ▸ | MLST8 | Q9BVC4 | 4/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 7/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.31 |
| ▸ | KIF5B | P33176 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | ETV6 | P41212 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | CCDC6 | Q16204 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2732777 | 0.94 | MTOR (0.45) | MTORRPTORMLST8DGAT1CHEK1 | |
| SCHEMBL29191 | 0.92 | MTOR (0.37) | MTORRPTORMLST8DGAT1RET | |
| SCHEMBL15026304 | 0.92 | MTOR (0.37) | MTORRPTORMLST8DGAT1RET | |
| SCHEMBL14316977 | 0.91 | DGAT1 (0.36) | MTORRPTORMLST8DGAT1CHEK1 | |
| SCHEMBL12503595 | 0.87 | MTOR (0.38) | MTORRPTORMLST8DGAT1CHEK1 | |
| SCHEMBL16086955 | 0.86 | DGAT1 (0.41) | MTORRPTORMLST8DGAT1CHEK1 | |
| SCHEMBL12460330 | 0.86 | MTOR (0.42) | MTORRPTORMLST8DGAT1CHEK1 | |
| SCHEMBL12461161 | 0.86 | MTOR (0.42) | MTORRPTORMLST8DGAT1CHEK1 | |
| SCHEMBL30182 | 0.86 | MTOR (0.42) | MTORRPTORMLST8DGAT1CHEK1 | |
| SCHEMBL12503608 | 0.86 | MTOR (0.42) | MTORRPTORMLST8DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2608668-A1 | FUSED TRICYCLIC INHIBITORS OF MAMMALIAN TARGET OF RAPAMYCIN | Merck Sharp & Dohme Corp. (US) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012027234-A1 | FUSED TRICYCLIC INHIBITORS OF MAMMALIAN TARGET OF RAPAMYCIN | SCHERING CORPORATION (US) | 2012-03-01 | — | — | WO | disclosed |