Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 0.60 |
| ▸ | TEK | Q02763 | 8/20 | 0.59 |
| ▸ | AURKA | O14965 | 7/20 | 0.59 |
| ▸ | MET | P08581 | 6/20 | 0.59 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.59 |
| ▸ | LCK | P06239 | 6/20 | 0.59 |
| ▸ | FLT1 | P17948 | 3/20 | 0.59 |
| ▸ | LYN | P07948 | 2/20 | 0.59 |
| ▸ | PDGFRA | P16234 | 8/20 | 0.58 |
| ▸ | KIT | P10721 | 4/20 | 0.50 |
| ▸ | AXL | P30530 | 3/20 | 0.50 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.50 |
| ▸ | RET | P07949 | 3/20 | 0.49 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.49 |
| ▸ | STK10 | O94804 | 2/20 | 0.49 |
| ▸ | ABL1 | P00519 | 2/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.49 |
| ▸ | BCR | P11274 | 2/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.49 |
| ▸ | FLT4 | P35916 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12673812 | 0.94 | KDR (0.55) | KDRTEKAURKAMETAURKB | |
| SCHEMBL12499932 | 0.92 | KDR (0.59) | KDRTEKAURKAMETAURKB | |
| SCHEMBL1900481 | 0.91 | KDR (0.61) | KDRTEKAURKAMETAURKB | |
| SCHEMBL1894605 | 0.90 | KDR (0.64) | KDRTEKAURKAMETAURKB | |
| SCHEMBL13627325 | 0.87 | KDR (0.55) | KDRTEKAURKAMETAURKB | |
| SCHEMBL12673919 | 0.86 | KDR (0.59) | KDRTEKAURKAMETAURKB | |
| SCHEMBL13627611 | 0.86 | KDR (0.61) | KDRTEKAURKAMETAURKB | |
| SCHEMBL6798959 | 0.86 | KDR (0.65) | KDRTEKAURKAMETAURKB | |
| SCHEMBL1249606 | 0.85 | KDR (0.58) | KDRTEKAURKAMETAURKB | |
| SCHEMBL12503740 | 0.85 | KDR (0.68) | KDRTEKAURKAMETAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7973160-B2 | Nitrogen-containing aromatic derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2011-07-05 | — | — | US | disclosed |
| US-20100197911-A1 | Nitrogen-Containing Aromatic Derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-08-05 | — | — | US | disclosed |
| US-7612092-B2 | Urea derivatives containing aromatic or heteroaromatic rings; 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide; prophylactic or therapeutic agent for a disease for which angiogenesis inhibition is effective | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2009-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100197911-A1 | Nitrogen-Containing Aromatic Derivatives | GNG2, GCG, FRG1 | KDR 2687/4885TEK 3916/4885AURKA 1006/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.