Known targets — ChEMBL curated mechanism
rplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrpmArpmBrpmCrpmDrpmE2rpmFrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsU
The experimentally established mechanism targets of Troleandomycin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 13/20 | 1.00 |
| ▸ | USP2 | O75604 | 4/20 | 1.00 |
| ▸ | ABCB1 | P08183 | 3/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 0.71 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | SLCO1B3 | Q9NPD5 | 2/20 | 0.38 |
| ▸ | SLCO1B1 | Q9Y6L6 | 2/20 | 0.38 |
| ▸ | MLNR | O43193 | 4/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ALB | P02768 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Troleandomycin SCHEMBL125071 | 1.00 | CYP3A4 (1.00) | CYP3A4USP2ABCB1LMNAPGR | |
| Troleandomycin SCHEMBL29470683 | 1.00 | CYP3A4 (1.00) | CYP3A4USP2ABCB1LMNAPGR | |
| Troleandomycin SCHEMBL664623 | 1.00 | CYP3A4 (1.00) | CYP3A4USP2ABCB1LMNAPGR | |
| Troleandomycin SCHEMBL28198745 | 0.97 | CYP3A4 (0.94) | CYP3A4USP2ABCB1LMNAPGR | |
| Troleandomycin SCHEMBL3065803 | 0.89 | CYP3A4 (0.79) | CYP3A4USP2ABCB1LMNAPGR | |
| SCHEMBL15944213 | 0.89 | CYP3A4 (0.80) | CYP3A4USP2ABCB1LMNAPGR | |
| Diproleandomycin SCHEMBL2109038 | 0.88 | CYP3A4 (0.78) | CYP3A4USP2ABCB1LMNAPGR | |
| SCHEMBL26436882 | 0.84 | CYP3A4 (0.72) | CYP3A4USP2ABCB1LMNAPGR | |
| Oleandomycin SCHEMBL3716 | 0.83 | CYP3A4 (1.00) | CYP3A4USP2ABCB1LMNASLCO1B3 | |
| Oleandomycin SCHEMBL10028439 | 0.83 | CYP3A4 (1.00) | CYP3A4USP2ABCB1LMNASLCO1B3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 15564 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260139860-A1 | PRODUCTS OF MANUFACTURE FOR THE TREATMENT, PREVENTION AND AMELIORATION OF MICROBIAL INFECTIONS | CENTRE FOR DIGESTIVE DISEASES (AU) | 2026-05-21 | — | — | US | claimed |
| US-12629363-B2 | Prophylaxis and treatment of angioedema | PHARVARIS GMBH (CH) | 2026-05-19 | — | — | US | claimed |
| US-12616708-B2 | Methods for treating pulmonary non-tuberculous mycobacterial infections | INSMED INCORPORATED (US) | 2026-05-05 | — | — | US | claimed |
| US-20260108619-A1 | CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LINKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS | HANGZHOU DAC BIOTECH CO., LTD. (CN) | 2026-04-23 | — | — | US | claimed |
| US-20260097039-A1 | METHODS FOR TREATING A FATTY LIVER DISEASE | MADRIGAL PHARMACEUTICALS INC (US) | 2026-04-09 | — | — | US | claimed |
| US-12576124-B2 | Formulation of a conjugate of a tubulysin analog to a cell-binding molecule | HANGZHOU DAC BIOTECH CO., LTD (CN) | 2026-03-17 | — | — | US | claimed |
| US-20260034154-A1 | METHODS FOR TREATING NEWLY DIAGNOSED MYCOBACTERIUM AVIUM COMPLEX LUNG INFECTIONS | INSMED INCORPORATED (US) | 2026-02-05 | — | — | US | claimed |
| EP-4680248-A1 | PRODUCTS OF MANUFACTURE AND THERAPEUTIC COMPOSITIONS FOR TREATING, AMELIORATING OR PREVENTING VIRAL INFECTIONS AND METHODS FOR MAKING AND USING THEM | Topelia Aust Limited (ACN 652 771 670) (AU) | 2026-01-21 | — | — | EP | claimed |
| US-20260007719-A1 | COMPOSITION FOR INTERMITTENT DOSING OF CALCINEURIN INHIBITORS | KLEE TREVOR (US) | 2026-01-08 | — | — | US | claimed |
| EP-4674894-A2 | COPOLYMERS OF N-VINYLPYRROLIDONE WITH FUNCTIONALIZED MALEIC ACID MOIETIES | Hemoteq AG (DE) | 2026-01-07 | — | — | EP | claimed |
| WO-1996012487-A1 | COMBINATION METHOD FOR ACNE TREATMENT | MERCK & CO., INC. (US) | 1996-05-02 | — | — | WO | claimed |
| WO-1996011684-A1 | METHOD FOR TOPICAL INHIBITION OF THE METABOLIC ACTIVITY OF CYTOCHROME P-450 | TWK, INC. (US) | 1996-04-25 | — | — | WO | claimed |
| US-5472954-A | Combining cyclodextrin with polymer before adding active material | CYCLOPS H.F. (IS) | 1995-12-05 | — | — | US | claimed |
| WO-1995018865-A1 | METHOD TO DIAGNOSE AND TREAT ALLERGIC INFLAMMATION | NATIONAL JEWISH CENTER FOR IMMUNOLOGY AND RESPIRATORY MEDICINE (US) | 1995-07-13 | — | — | WO | claimed |
| US-5288503-A | WATER-PERMEABLE DIFFUSION BARRIER OF POLYVINYL ALCOHOL | SRCHEM INCORPORATED (US) | 1994-02-22 | — | — | US | claimed |
| US-5260066-A | Cryogel bandage containing therapeutic agent | SRCHEM INCORPORATED (US) | 1993-11-09 | — | — | US | claimed |
| US-5051262-A | Processes for the preparation of delayed action and programmed release pharmaceutical forms and medicaments obtained thereby | ELAN CORP., P.L.C. (IE) | 1991-09-24 | — | — | US | claimed |
| EP-0273202-A2 | Use of hydroxycarboxylic acids to enhance therapeutic effects of topical compositions for fungal infections and pigmented spots. | Van Scott, Eugene J., Dr. (US) | 1988-07-06 | — | — | EP | claimed |
| US-4726951-A | New pharmaceutical forms for administration of medicaments by oral route, with programmed release | ELAN CORPORATION P.L.C. (IE) | 1988-02-23 | — | — | US | claimed |
| US-4069322-A | Pro-drugs for the improved delivery of certain selected anti-inflammatory steroids | INTERX RESEARCH CORPORATION (US) | 1978-01-17 | — | — | US | claimed |