Oleandomycin

Oleandomycin

SCHEMBL3716

CO[C@H]1C[C@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@@H](C)C[C@]3(CO3)C(=O)[C@H](C)[C@@H](O)[C@@H](C)[C@@H](C)OC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 12/20 1.00
LMNA P02545 3/20 1.00
ABCB1 P08183 3/20 0.71
USP2 O75604 2/20 0.71
MLNR O43193 4/20 0.45
KCNH2 Q12809 5/20 0.44
AR P10275 1/20 0.44
MAPK1 P28482 1/20 0.44
SLCO1B3 Q9NPD5 1/20 0.44
SLCO1B1 Q9Y6L6 1/20 0.44
TSHR P16473 2/20 0.43
TDP1 Q9NUW8 1/20 0.43
ALB P02768 1/20 0.43
CNR1 P21554 1/20 0.43
HTR2A P28223 1/20 0.43
AOX1 Q06278 1/20 0.43
CYP1B1 Q16678 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Oleandomycin SCHEMBL3717 1.00 CYP3A4 (1.00) CYP3A4LMNAABCB1USP2MLNR
Oleandomycin SCHEMBL29684259 1.00 CYP3A4 (1.00) CYP3A4LMNAABCB1USP2MLNR
Oleandomycin SCHEMBL10028439 1.00 CYP3A4 (1.00) CYP3A4LMNAABCB1USP2MLNR
Oleandomycin SCHEMBL9807053 0.99 CYP3A4 (0.99) CYP3A4LMNAABCB1USP2MLNR
Oleandomycin SCHEMBL950913 0.98 CYP3A4 (0.96) CYP3A4LMNAABCB1USP2MLNR
Oleandomycin SCHEMBL5033021 0.97 CYP3A4 (1.00) CYP3A4LMNAABCB1USP2MLNR
Oleandomycin SCHEMBL285338 0.97 CYP3A4 (1.00) CYP3A4LMNAABCB1USP2MLNR
SCHEMBL11029029 0.92 CYP3A4 (0.85) CYP3A4LMNAABCB1USP2MLNR
Diproleandomycin SCHEMBL2109038 0.87 CYP3A4 (0.78) CYP3A4LMNAABCB1USP2MLNR
SCHEMBL5551907 0.86 CYP3A4 (0.74) CYP3A4LMNAABCB1USP2MLNR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 8673 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260139860-A1 PRODUCTS OF MANUFACTURE FOR THE TREATMENT, PREVENTION AND AMELIORATION OF MICROBIAL INFECTIONS CENTRE FOR DIGESTIVE DISEASES (AU) 2026-05-21 US claimed
US-12616708-B2 Methods for treating pulmonary non-tuberculous mycobacterial infections INSMED INCORPORATED (US) 2026-05-05 US claimed
US-20260108619-A1 CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LINKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS HANGZHOU DAC BIOTECH CO., LTD. (CN) 2026-04-23 US claimed
US-12576124-B2 Formulation of a conjugate of a tubulysin analog to a cell-binding molecule HANGZHOU DAC BIOTECH CO., LTD (CN) 2026-03-17 US claimed
US-20260034154-A1 METHODS FOR TREATING NEWLY DIAGNOSED MYCOBACTERIUM AVIUM COMPLEX LUNG INFECTIONS INSMED INCORPORATED (US) 2026-02-05 US claimed
EP-4680248-A1 PRODUCTS OF MANUFACTURE AND THERAPEUTIC COMPOSITIONS FOR TREATING, AMELIORATING OR PREVENTING VIRAL INFECTIONS AND METHODS FOR MAKING AND USING THEM Topelia Aust Limited (ACN 652 771 670) (AU) 2026-01-21 EP claimed
EP-4673157-A2 COMPOSITIONS FOR MODULATING GUT MICROFLORA POPULATIONS, TREATMENT OF DYSBIOSIS AND DISEASE PREVENTION, AND METHODS FOR MAKING AND USING SAME Persephone Biosciences, Inc. (US) 2026-01-07 EP claimed
WO-2025264805-A2 SYNBIOTICS FOR MODULATING GUT MICROFLORA POPULATIONS, TREATMENT OF DYSBIOSIS AND DISEASE PREVENTION, AND METHODS FOR MAKING AND USING SAME PERSEPHONE BIOSCIENCES, INC. (US) 2025-12-26 WO claimed
US-20250339551-A1 AN ANTIBODY-DRUG CONJUGATE HAVING TWO OR MORE DIFFERENT FUNCTIONAL SMALL MOLECULES FOR ENHANCED TREATMENT OF REFRACTORY DISEASES HANGZHOU SEEHE BIOTECHNOLOGY CO., LTD (CN) 2025-11-06 US claimed
US-20250325574-A1 METHODS FOR TREATING PULMONARY NON-TUBERCULOUS MYCOBACTERIAL INFECTIONS INSMED INCORPORATED (US) 2025-10-23 US claimed
US-4429116-A Alkylated oleandomycin containing compounds PFIZER INC. (US) 1984-01-31 US claimed
US-4414204-A WITH A MURAMYL-PEPTIDE CIBA-GEIGY CORPORATION (US) 1983-11-08 US claimed
EP-0088943-A2 Composition for the resorption of injected antibacterial substances and mixtures containing a benzyl amine derivative BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) 1983-09-21 EP claimed
EP-0087915-A1 Semi-synthetic oleandomycins and erythromycins PFIZER INC. (US) 1983-09-07 EP claimed
EP-0056290-A2 Novel macrolidic antibiotics having antibiotic activity, process and microorganism for their preparation, and related pharmaceutical compositions Pierrel S.p.A. (IT) 1982-07-21 EP claimed
EP-0041114-A2 Process for the preparation of medicated animal feed supplement AMERICAN CYANAMID COMPANY (US) 1981-12-09 EP claimed
EP-0035770-A2 An orally administered drug form comprising a glycosidic antibiotic and an adjuvant INTERx RESEARCH CORPORATION (US) 1981-09-16 EP claimed
EP-0032304-A1 Antibiotic compositions ELI LILLY AND COMPANY (US) 1981-07-22 EP claimed
US-4239750-A CHICKENS AND PIGS HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (HENKEL KGAA) (DE) 1980-12-16 US claimed
EP-0019809-A1 Animal feed mixture Henkel Kommanditgesellschaft auf Aktien (DE) 1980-12-10 EP claimed