Diproleandomycin

Diproleandomycin

SCHEMBL2109038

CCC(=O)O[C@H]1[C@H](C)O[C@@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@@H](C)C[C@]3(CO3)C(=O)[C@H](C)[C@@H](OC(=O)CC)[C@@H](C)[C@@H](C)OC(=O)[C@@H]2C)C[C@@H]1OC

nearest known ligand 0.78

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 12/20 0.78
ABCB1 P08183 3/20 0.78
USP2 O75604 2/20 0.78
LMNA P02545 3/20 0.77
PGR P06401 1/20 0.44
HTR1A P08908 1/20 0.44
DRD1 P21728 1/20 0.44
SLC6A2 P23975 1/20 0.44
OPRM1 P35372 1/20 0.44
DRD3 P35462 1/20 0.44
SLC6A3 Q01959 1/20 0.44
MLNR O43193 4/20 0.44
KCNH2 Q12809 4/20 0.44
AR P10275 1/20 0.44
MAPK1 P28482 1/20 0.44
SLCO1B3 Q9NPD5 1/20 0.44
SLCO1B1 Q9Y6L6 1/20 0.44
TSHR P16473 2/20 0.43
TDP1 Q9NUW8 1/20 0.43
ALB P02768 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Troleandomycin SCHEMBL125071 0.88 CYP3A4 (1.00) CYP3A4ABCB1USP2LMNAPGR
Troleandomycin SCHEMBL29470683 0.88 CYP3A4 (1.00) CYP3A4ABCB1USP2LMNAPGR
Troleandomycin SCHEMBL125070 0.88 CYP3A4 (1.00) CYP3A4ABCB1USP2LMNAPGR
Troleandomycin SCHEMBL664623 0.88 CYP3A4 (1.00) CYP3A4ABCB1USP2LMNAPGR
Oleandomycin SCHEMBL10028439 0.87 CYP3A4 (1.00) CYP3A4ABCB1USP2LMNAMLNR
Oleandomycin SCHEMBL3716 0.87 CYP3A4 (1.00) CYP3A4ABCB1USP2LMNAMLNR
Oleandomycin SCHEMBL29684259 0.87 CYP3A4 (1.00) CYP3A4ABCB1USP2LMNAMLNR
Oleandomycin SCHEMBL3717 0.87 CYP3A4 (1.00) CYP3A4ABCB1USP2LMNAMLNR
Oleandomycin SCHEMBL950913 0.86 CYP3A4 (0.96) CYP3A4ABCB1USP2LMNAMLNR
Oleandomycin SCHEMBL9807053 0.86 CYP3A4 (0.99) CYP3A4ABCB1USP2LMNAMLNR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3932409-A1 COMPOUNDS FOR THE TREATMENT AND PREVENTION OF VIRAL INFECTIONS CAUSED BY CORONAVIRUSES Consejo Superior de Investigaciones Científicas (CSIC) (ES) 2022-01-05 EP claimed
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US claimed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 US claimed
CN-101330905-A Freeze-drying process and products obtained thereby SCIDOSE LLC (US) 2008-12-24 CN claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 EP claimed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 WO claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 US claimed
US-20220047505-A1 Controlled Absorption Water-Soluble Pharmaceutically Active Organic Compound Formulation for Once-Daily Administration STI PHARMA, LLC (US) 2022-02-17 US disclosed
WO-2022002789-A1 COMPOUNDS SELECTED FROM CLARITHROMYCIN AND LEXITHROMYCIN FOR THE TREATMENT AND PREVENTION OF VIRAL INFECTIONS CAUSED BY CORONAVIRUSES CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC) (ES) 2022-01-06 WO disclosed
EP-3932409-A1 COMPOUNDS FOR THE TREATMENT AND PREVENTION OF VIRAL INFECTIONS CAUSED BY CORONAVIRUSES Consejo Superior de Investigaciones Científicas (CSIC) (ES) 2022-01-05 EP disclosed
US-11191719-B2 Controlled absorption water-soluble pharmaceutically active organic compound formulation for once-daily administration STI PHARMA, LLC (US) 2021-12-07 US disclosed
US-10463611-B2 Controlled absorption water-soluble pharmaceutically active organic compound formulation for once-daily administration STI PHARMA, LLC (US) 2019-11-05 US disclosed
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US disclosed
US-20040141922-A1 Diagnostic/therapeutic agents NYCOMED IMAGING AS 2004-07-22 US disclosed
US-6680047-B2 FOR USE IN ULTRASOUND IMAGING, CONTRAST AGENTS AMERSHAM HEALTH AS (NO) 2004-01-20 US disclosed
US-20020102215-A1 Diagnostic/therapeutic agents NYCOMED IMAGING AS 2002-08-01 US disclosed
US-20020102217-A1 Diagnostic/therapeutic agents NYCOMED IMAGING AS 2002-08-01 US disclosed
US-6331289-B1 ULTRASOUND CONTRAST AGENTS, SUSPENSION IN AQUEOUS CARRIER LIQUID OF A REPORTER COMPRISING GAS-CONTAINING OR GAS-GENERATING MATERIAL, AGENT CAPABLE OF FORMING AT LEAST TWO TYPES OF BINDING PAIRS WITH TARGET; REPORTER BEING CONJUGATED NYCOMED IMAGING AS (NO) 2001-12-18 US disclosed
US-6264917-B1 MIXTURE OF GAS FILLED MICROBUBBLES AND RELEASING AGENT NYCOMED IMAGING AS (NO) 2001-07-24 US disclosed
US-6261537-B1 TARGETS AND ULTRASOUND DIAGNOSIS OF ACTIVE MATERIALS, AQUEOUS CARRIER LIQUIDS, CARRIERS AND FILM FORMING SURFACTANT PHOSPHATIDES NYCOMED IMAGING AS (NO) 2001-07-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040141922-A1 Diagnostic/therapeutic agents BID, FUS, FABP1 CYP3A4 4858/4885ABCB1 1042/4885USP2 653/4885
US-20020102215-A1 Diagnostic/therapeutic agents BID, FUS, FABP1 CYP3A4 4863/4885ABCB1 1312/4885USP2 725/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.