Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 7/20 | 0.70 |
| ▸ | SYK | P43405 | 5/20 | 0.70 |
| ▸ | SRC | P12931 | 3/20 | 0.70 |
| ▸ | ZAP70 | P43403 | 3/20 | 0.70 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.60 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.60 |
| ▸ | ABL1 | P00519 | 1/20 | 0.60 |
| ▸ | BCR | P11274 | 1/20 | 0.60 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.57 |
| ▸ | CDK1 | P06493 | 2/20 | 0.55 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.55 |
| ▸ | RET | P07949 | 1/20 | 0.55 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.55 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7475231 | 0.90 | SYK (0.66) | CDK2SYKSRCZAP70PIK3CA | |
| SCHEMBL7473582 | 0.84 | CDK2 (0.65) | CDK2SYKSRCZAP70PIK3CA | |
| SCHEMBL7471189 | 0.84 | SYK (0.50) | CDK2SYKSRCZAP70PIK3CA | |
| SCHEMBL7468142 | 0.84 | PIK3CG (0.67) | CDK2SYKSRCZAP70PIK3CA | |
| SCHEMBL7471621 | 0.84 | MEN1 (0.59) | CDK2SYKABL1CDK1CCNB2 | |
| SCHEMBL12423706 | 0.82 | PIK3CG (0.68) | CDK2SYKSRCZAP70PIK3CA | |
| SCHEMBL13924432 | 0.82 | SYK (1.00) | CDK2SYKSRCZAP70PIK3CA | |
| SCHEMBL12423167 | 0.81 | PIK3CG (0.66) | CDK2SYKSRCZAP70PIK3CA | |
| SCHEMBL2198846 | 0.81 | CDK2 (0.61) | CDK2SYKSRCZAP70PIK3CA | |
| SCHEMBL12509736 | 0.81 | CDK2 (0.55) | CDK2SYKSRCZAP70PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |
| EP-0233461-B1 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 1996-03-20 | — | — | EP | disclosed |