Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARG | P13631 | 4/20 | 0.43 |
| ▸ | RXRA | P19793 | 13/20 | 0.39 |
| ▸ | RXRB | P28702 | 8/20 | 0.36 |
| ▸ | RXRG | P48443 | 8/20 | 0.36 |
| ▸ | RARA | P10276 | 3/20 | 0.36 |
| ▸ | RARB | P10826 | 3/20 | 0.36 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.36 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12517437 | 0.86 | RARG (0.43) | RARGRXRARXRBRXRGRARA | |
| SCHEMBL12517008 | 0.81 | RXRA (0.52) | RARGRXRARXRBRXRGRARA | |
| SCHEMBL8749985 | 0.80 | RARG (0.42) | RARGRXRARXRBRXRGRARA | |
| SCHEMBL8750003 | 0.80 | RARG (0.44) | RARGRXRARXRBRXRGRARA | |
| SCHEMBL24084733 | 0.78 | RARG (0.44) | RARGRXRARXRBRXRGRARA | |
| SCHEMBL9299399 | 0.77 | RARG (0.52) | RARGRXRARXRBRXRGRARA | |
| SCHEMBL110818 | 0.77 | RARG (0.52) | RARGRXRARXRBRXRGRARA | |
| SCHEMBL14414059 | 0.77 | RARG (0.58) | RARGRXRARXRBRXRGRARA | |
| SCHEMBL23633279 | 0.77 | RARG (0.52) | RARGRXRARXRBRXRGRARA | |
| SCHEMBL10689218 | 0.77 | RARG (0.52) | RARGRXRARXRBRXRGRARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011082732-A1 | SPHINGOSINE KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2011-07-14 | — | — | WO | disclosed |