Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.41 |
| ▸ | TNNI3K | Q59H18 | 2/20 | 0.41 |
| ▸ | CDK8 | P49336 | 2/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.38 |
| ▸ | GOT1 | P17174 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | AHR | P35869 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14689713 | 0.74 | DDR2 (0.60) | MAPK14KITKDM4EMAPTHTT | |
| SCHEMBL17208650 | 0.74 | MAPT (0.56) | RXFP1KDM4EMAPTHTT | |
| SCHEMBL17208652 | 0.71 | PIKFYVE (0.56) | BRAFKDRKIT | |
| SCHEMBL16581617 | 0.68 | CSK (0.63) | BRAFKDRMAPK14KIT | |
| SCHEMBL16581618 | 0.68 | CSK (0.63) | BRAFKDRMAPK14KIT | |
| SCHEMBL22457384 | 0.68 | MAPK14 (0.61) | BRAFKDRMAPK14KITKDM4E | |
| SCHEMBL17208612 | 0.68 | MAPK14 (0.53) | BRAFKDRMAPK14KIT | |
| SCHEMBL4790006 | 0.67 | RAF1 (0.51) | BRAFKDRMAPK14KITRXFP1 | |
| SCHEMBL17208706 | 0.67 | DDR1 (0.55) | BRAFMAPK14RXFP1KDM4EMAPT | |
| SCHEMBL14689711 | 0.66 | KDR (0.50) | BRAFKDRMAPK14KITMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011090738-A2 | TYPE II RAF KINASE INHIBITORS | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2011-07-28 | — | — | WO | disclosed |