Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 2/20 | 0.44 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 4/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12516086 | 0.85 | GRM5 (0.46) | P2RX7GRM5SMN1; SMN2CDK2CDK5 | |
| SCHEMBL12517184 | 0.83 | GRM5 (0.44) | P2RX7CNR2GRM5CDK2CDK5 | |
| SCHEMBL12516088 | 0.82 | GRM5 (0.44) | P2RX7GRM5 | |
| SCHEMBL12516090 | 0.81 | GRM5 (0.41) | P2RX7CNR2GRM5CDK2CDK5 | |
| SCHEMBL12517295 | 0.79 | HSD11B1 (0.53) | GRM5 | |
| SCHEMBL12516075 | 0.78 | GRM5 (0.46) | P2RX7GRM5CDK2CDK5CDK5R1 | |
| SCHEMBL2276932 | 0.77 | GRM5 (0.48) | P2RX7P2RX4CNR2MEN1KMT2A | |
| SCHEMBL30795223 | 0.77 | GRM5 (0.48) | P2RX7P2RX4CNR2MEN1KMT2A | |
| SCHEMBL12517655 | 0.76 | GRM5 (0.44) | P2RX7GRM5CDK2CDK5CDK5R1 | |
| SCHEMBL12516092 | 0.74 | GRM5 (0.35) | P2RX7GRM5CDK2CDK5CDK5R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011087758-A1 | ADAMANTYL AMIDE DERIVATIVES AND USES OF SAME | H. LUNDBECK A/S (DK) | 2011-07-21 | — | — | WO | disclosed |