Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 4/20 | 0.35 |
| ▸ | CDK2 | P24941 | 8/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 8/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 8/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 7/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.32 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.31 |
| ▸ | F2R | P25116 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12516090 | 0.82 | GRM5 (0.41) | GRM5CDK2CDK5CDK5R1CCNA2 | |
| SCHEMBL12516086 | 0.79 | GRM5 (0.46) | GRM5CDK2CDK5CDK5R1CCNA2 | |
| SCHEMBL12517184 | 0.78 | GRM5 (0.44) | GRM5CDK2CDK5CDK5R1CCNA2 | |
| SCHEMBL12516088 | 0.76 | GRM5 (0.44) | GRM5P2RX7HSD11B1 | |
| SCHEMBL12517183 | 0.74 | P2RX7 (0.44) | GRM5CDK2CDK5CDK5R1CCNA2 | |
| SCHEMBL12517295 | 0.73 | HSD11B1 (0.53) | GRM5HSD11B1 | |
| SCHEMBL12516390 | 0.72 | GRM5 (0.41) | GRM5CDK2CDK5CDK5R1CCNA2 | |
| SCHEMBL12516075 | 0.72 | GRM5 (0.46) | GRM5CDK2CDK5CDK5R1CCNA2 | |
| SCHEMBL12517655 | 0.71 | GRM5 (0.44) | GRM5CDK2CDK5CDK5R1CCNA2 | |
| SCHEMBL12516399 | 0.68 | HDAC6 (0.41) | GRM5CDK2CDK5CDK5R1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011087758-A1 | ADAMANTYL AMIDE DERIVATIVES AND USES OF SAME | H. LUNDBECK A/S (DK) | 2011-07-21 | — | — | WO | disclosed |