Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.74 |
| ▸ | RRM1 | P23921 | 2/20 | 0.67 |
| ▸ | RRM2 | P31350 | 2/20 | 0.67 |
| ▸ | RRM2B | Q7LG56 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 5/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | KDM1A | O60341 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | NSD2 | O96028 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MPI | P34949 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1030790 | 0.85 | KMT2A (0.71) | MAPTLMNAKMT2AMEN1RAB9A | |
| SCHEMBL14445009 | 0.85 | KMT2A (0.71) | MAPTLMNAKMT2AMEN1RAB9A | |
| SCHEMBL12826251 | 0.85 | KDM4E (0.54) | MAPTRRM1RRM2RRM2BLMNA | |
| SCHEMBL12453426 | 0.83 | MAPT (0.68) | MAPTRRM1RRM2RRM2BLMNA | |
| SCHEMBL15457449 | 0.79 | L3MBTL1 (0.74) | MAPTLMNAKMT2AMEN1RAB9A | |
| SCHEMBL5375954 | 0.78 | MAPT (0.63) | MAPTRRM1RRM2RRM2BLMNA | |
| SCHEMBL5375949 | 0.78 | MAPT (0.63) | MAPTRRM1RRM2RRM2BLMNA | |
| SCHEMBL12453311 | 0.77 | KMT2A (0.65) | MAPTRRM1RRM2RRM2BLMNA | |
| SCHEMBL684939 | 0.74 | KDM1A (1.00) | MAPTLMNAKMT2AMEN1RAB9A | |
| SCHEMBL26991 | 0.73 | IDO1 (0.79) | MAPTKMT2AMEN1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020123675-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER | DUKE UNIVERSITY (US) | 2020-06-18 | — | — | WO | disclosed |
| US-20120238604-A1 | CYTOTOXIC COMPOUNDS | MOLECULAR DISCOVERY SYSTEMS (AU) | 2012-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120238604-A1 | CYTOTOXIC COMPOUNDS | BAX, MKI67, EPCAM | MAPT 2176/4885RRM1 4704/4885RRM2 4270/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.