SCHEMBL12528358

SCHEMBL12528358

Cc1cc(CO)c2nc(-c3cc(Br)nn3-c3ncccc3Cl)oc(=O)c2c1

nearest known ligand 0.41

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ DHODH Q02127 3/20 0.41
▸ RXFP1 Q9HBX9 1/20 0.31
▸ KDM4E B2RXH2 1/20 0.30
▸ ALDH1A1 P00352 1/20 0.30
▸ LMNA P02545 1/20 0.30
▸ HSP90AA1 P07900 1/20 0.30
▸ GAA P10253 1/20 0.30
▸ MAPT P10636 1/20 0.30
▸ TDP1 Q9NUW8 1/20 0.30
▸ L3MBTL1 Q9Y468 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12528630 0.89 DHODH (0.42) DHODHKDM4EALDH1A1MAPT
SCHEMBL12528168 0.88 DHODH (0.43) DHODHKDM4EALDH1A1MAPT
SCHEMBL950558 0.88 DHODH (0.41) DHODHKDM4EALDH1A1MAPT
SCHEMBL12528396 0.87 DHODH (0.42) DHODHKDM4EALDH1A1
SCHEMBL951196 0.86 DHODH (0.41) DHODHRXFP1KDM4EALDH1A1MAPT
SCHEMBL12911989 0.85 DHODH (0.40) DHODHKDM4EALDH1A1
SCHEMBL30560160 0.84 DHODH (0.47) DHODH
SCHEMBL841198 0.84 DHODH (0.47) DHODH
SCHEMBL12528721 0.83 DHODH (0.40) DHODHKDM4EALDH1A1
SCHEMBL950583 0.83 DHODH (0.42) DHODHKDM4EALDH1A1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7968573-B2 Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-06-28 — — US disclosed
US-20110071291-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME IKEGAMI HIROSHI 2011-03-24 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110071291-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME ACHE, H1-2, H1-0 DHODH 771/4885RXFP1 363/4885KDM4E 1084/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback