SCHEMBL12528501

SCHEMBL12528501

CNC(=O)c1cc(Cl)cc(C)c1NC(=O)c1cc(C)nn1C(C)C

nearest known ligand 0.51

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
KCNJ6 P48051 1/20 0.36
KCNJ5 P48544 1/20 0.36
KCNJ3 P48549 1/20 0.36
KMT2A Q03164 3/20 0.36
F10 P00742 5/20 0.35
MAPT P10636 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
FGFR1 P11362 1/20 0.34
BRD4 O60885 2/20 0.33
NTRK1 P04629 1/20 0.33
MEN1 O00255 1/20 0.33
FLT1 P17948 1/20 0.33
KDR P35968 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27256873 0.89 F10 (0.34) KMT2AF10BRD4MEN1
SCHEMBL12912031 0.86 PDE4B (0.38) F10
SCHEMBL12528518 0.82 GAA (0.50) KMT2AF10MAPTNPSR1MEN1
SCHEMBL12528467 0.82 MAPT (0.44) KMT2AMAPTNPSR1MEN1FLT1
SCHEMBL12528301 0.81 KMT2A (0.59) KMT2AF10MAPTNTRK1MEN1
SCHEMBL15357765 0.78 BRD4 (0.48) KCNJ6KCNJ5KCNJ3KMT2AMAPT
SCHEMBL30961111 0.78 PDE4B (0.37) F10
SCHEMBL27256880 0.78 PDE4B (0.33) KMT2AF10MEN1KDR
SCHEMBL30961151 0.78 PDE4B (0.33) KMT2AF10MEN1KDR
SCHEMBL12528610 0.78 KCNJ6 (0.42) KCNJ6KCNJ5KCNJ3F10KDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7968573-B2 Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-06-28 US disclosed
US-20110071291-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME IKEGAMI HIROSHI 2011-03-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110071291-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME ACHE, H1-2, H1-0 KCNJ6 210/4885KCNJ5 250/4885KCNJ3 258/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.