SCHEMBL12528540

SCHEMBL12528540

CNC(=O)c1cc(Cl)cc(C)c1NC(=O)c1cc(Br)cn1-c1ncccc1Cl

nearest known ligand 0.71

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
MALT1 Q9UDY8 6/20 0.38
DHODH Q02127 1/20 0.36
F10 P00742 1/20 0.36
S1PR1 P21453 1/20 0.34
S1PR3 Q99500 1/20 0.34
TRPV1 Q8NER1 1/20 0.33
PSD A5PKW4 1/20 0.33
SORT1 Q99523 1/20 0.33
GRM4 Q14833 1/20 0.33
DRD4 P21917 1/20 0.33
NPC1 O15118 1/20 0.32
HTT P42858 1/20 0.32
RAB9A P51151 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL951506 0.92 MALT1 (0.37) MALT1DHODHF10S1PR1S1PR3
SCHEMBL12528654 0.92 MALT1 (0.39) MALT1F10TRPV1GRM4DRD4
SCHEMBL12747480 0.91 MALT1 (0.39) MALT1DHODHF10TRPV1GRM4
SCHEMBL12911685 0.90 MALT1 (0.36) MALT1DHODHF10S1PR1S1PR3
SCHEMBL12528641 0.89 KMT2A (0.35) MALT1DHODHS1PR1S1PR3TRPV1
SCHEMBL12528629 0.89 MALT1 (0.36) MALT1DHODHF10S1PR1S1PR3
SCHEMBL12528697 0.89 MALT1 (0.38) MALT1DHODHF10TRPV1GRM4
SCHEMBL13072870 0.89 ALDH1A1 (0.37) MALT1DHODHF10S1PR1S1PR3
SCHEMBL13318590 0.89 MALT1 (0.35) MALT1DHODHF10S1PR1S1PR3
SCHEMBL951437 0.89 MALT1 (0.35) MALT1DHODHF10S1PR1S1PR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7968573-B2 Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-06-28 US disclosed
US-7867949-B2 Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-11 US disclosed
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-07-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same ACHE, DDT, CAT MALT1 4865/4885DHODH 284/4885F10 3713/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.