SCHEMBL12528813

SCHEMBL12528813

Cc1cc(C)c2nc(-c3cc(Br)cn3-c3ccncc3Cl)oc(=O)c2c1

nearest known ligand 0.34

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 2/20 0.31
▸ MEN1 O00255 1/20 0.31
▸ ALDH1A1 P00352 1/20 0.31
▸ POLB P06746 1/20 0.31
▸ KMT2A Q03164 1/20 0.31
▸ PTK2B Q14289 1/20 0.31
▸ HCAR1 Q9BXC0 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL950650 0.93 KDM4E (0.31) KDM4EHCAR1
SCHEMBL12528677 0.86 PARP1 (0.31) KDM4EMEN1ALDH1A1POLBKMT2A
SCHEMBL12528711 0.83 MEN1 (0.32) KDM4EMEN1ALDH1A1POLBKMT2A
SCHEMBL12528672 0.82 PBRM1 (0.34) KDM4EMEN1ALDH1A1POLBKMT2A
SCHEMBL12528536 0.81 TRPV1 (0.36) KDM4EMEN1ALDH1A1POLBKMT2A
SCHEMBL14495052 0.80 ALDH1A1 (0.34) KDM4EALDH1A1POLB
SCHEMBL952168 0.79 KDM4E (0.31) KDM4E
SCHEMBL950950 0.76 F2 (0.31) —
SCHEMBL950603 0.75 ALDH1A1 (0.36) KDM4EALDH1A1POLB
SCHEMBL12528603 0.74 TRPV1 (0.34) KDM4EMEN1ALDH1A1POLBKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7968573-B2 Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-06-28 — — US disclosed
US-20110071291-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME IKEGAMI HIROSHI 2011-03-24 — — US disclosed
US-7867949-B2 Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-11 — — US disclosed
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-07-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110071291-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME ACHE, H1-2, H1-0 KDM4E 1084/4885MEN1 1030/4885ALDH1A1 238/4885
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same ACHE, DDT, CAT KDM4E 2028/4885MEN1 1803/4885ALDH1A1 436/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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